Mouse Anti-LYZ Recombinant Antibody (LYZ-Z) (CBMAB-L2558-YJ)

Name: Mouse Anti-LYZ Recombinant Antibody (LYZ-Z)
SKU: CBMAB-L2558-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

LYZ-Z

Application

FC, IF, IHC-Fr, IHC-P

Immunogen

Human Lysozyme.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LYZ

Introduction

Lysozyme's natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, plasma, kidney, white blood cells, saliva, and tears. Lysozyme has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.

Entrez Gene ID

4069

UniProt ID

P61626

Alternative Names

LZM; LYZF1; lysozyme C; 1,4-beta-N-acetylmuramidase C; c-type lysozyme; lysozyme F1; EC 3.2.1.17

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Biological Process

Antimicrobial humoral responseTAS:Reactome
CytolysisIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Metabolic processIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Secreted

Involvement in disease

Amyloidosis 8 (AMYL8):
A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.

Nawaz, N., Wen, S., Wang, F., Nawaz, S., Raza, J., Iftikhar, M., & Usman, M. (2022). Lysozyme and its application as antibacterial agent in food industry. Molecules, 27(19), 6305.

Hu, F., Wang, Y., Hu, J., Bao, Z., & Wang, M. (2022). A novel c-type lysozyme from Litopenaeus vannamei exhibits potent antimicrobial activity. Fish & Shellfish Immunology, 131, 729-735.

Moreno-Navarrete, J. M., Latorre, J., Lluch, A., Ortega, F. J., Comas, F., Arnoriaga-Rodríguez, M., ... & Fernández-Real, J. M. (2021). Lysozyme is a component of the innate immune system linked to obesity associated-chronic low-grade inflammation and altered glucose tolerance. Clinical Nutrition, 40(3), 1420-1429.

Li, L., Cardoso, J. C., Felix, R. C., Mateus, A. P., Canário, A. V., & Power, D. M. (2021). Fish lysozyme gene family evolution and divergent function in early development. Developmental & Comparative Immunology, 114, 103772.

Latorre, J., Lluch, A., Ortega, F. J., Gavaldà-Navarro, A., Comas, F., Morón-Ros, S., ... & Moreno-Navarrete, J. M. (2021). Adipose tissue knockdown of lysozyme reduces local inflammation and improves adipogenesis in high-fat diet-fed mice. Pharmacological Research, 166, 105486.

Wang, H., Shen, X., Zheng, X., Pan, Y., Zhang, Q., & Liu, Z. (2021). Intestinal lysozyme releases Nod2 ligand (s) to promote the intestinal mucosal adjuvant activity of cholera toxin. Science China Life Sciences, 64, 1720-1731.

Yu, S., Balasubramanian, I., Laubitz, D., Tong, K., Bandyopadhyay, S., Lin, X., ... & Gao, N. (2020). Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine. Immunity, 53(2), 398-416.

Jin, Y., Zeng, Q., Geng, F., & Ma, M. (2020). Characterization of the interaction between hen egg white lysozyme and ovalbumin: Interaction between lysozyme and ovalbumin. Food Bioscience, 36, 100674.

Li, H., Wei, X., Yang, J., Zhang, R., Zhang, Q., & Yang, J. (2019). The bacteriolytic mechanism of an invertebrate-type lysozyme from mollusk Octopus ocellatus. Fish & Shellfish Immunology, 93, 232-239.

Iwashita, K., Handa, A., & Shiraki, K. (2019). Co-aggregation of ovotransferrin and lysozyme. Food Hydrocolloids, 89, 416-424.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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