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Mouse Anti-LZTFL1 Recombinant Antibody (1B1) (CBMAB-A5143-LY)

The product is antibody recognizes LZTFL1. The antibody 1B1 immunoassay techniques such as: WB, ELISA.
See all LZTFL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
LZTFL1 (AAH25988.1, 39 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LZTFL1
Entrez Gene ID
54585
UniProt ID
Q9NQ48
Alternative Names
FLJ36386
Function
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Biological Process
Flagellated sperm motilityIEA:Ensembl
Negative regulation of protein localization to ciliary membraneManual Assertion Based On ExperimentIMP:GO_Central
Negative regulation of protein localization to ciliumManual Assertion Based On ExperimentIMP:GO_Central
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Bardet-Biedl syndrome 17 (BBS17):
A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.

Lu, J., Fu, L. M., Cao, Y., Fang, Y., Cao, J. Z., Pan, Y. H., ... & Luo, J. H. (2023). LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway. Oncogene, 42(19), 1543-1557.

Angulo-Aguado, M., Corredor-Orlandelli, D., Carrillo-Martínez, J. C., Gonzalez-Cornejo, M., Pineda-Mateus, E., Rojas, C., ... & Ortega-Recalde, O. (2022). Association between the LZTFL1 rs11385942 polymorphism and COVID-19 severity in Colombian population. Frontiers in Medicine, 9, 910098.

Fink-Baldauf, I. M., Stuart, W. D., Brewington, J. J., Guo, M., & Maeda, Y. (2022). CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1. EBioMedicine, 75.

Wang, H., Ma, P., Liu, P., Guo, D., Liu, Z., & Zhang, Z. (2021). lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization. Cancer Letters, 520, 121-131.

Downes, D. J., Cross, A. R., Hua, P., Roberts, N., Schwessinger, R., Cutler, A. J., ... & Hughes, J. R. (2021). Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. Nature genetics, 53(11), 1606-1615.

Huang, Q., Li, W., Zhou, Q., Awasthi, P., Cazin, C., Yap, Y., ... & Zhang, Z. (2021). Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility. Developmental Biology, 477, 164-176.

Sun, W. Y., Xue, B., Liu, Y. X., Zhang, R. K., Li, R. C., Xin, W., ... & Fan, Z. C. (2021). Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip. Proceedings of the National Academy of Sciences, 118(35), e2101590118.

Li, S., Li, J., & Yu, Z. (2019). Tumor suppressive functions of LZTFL1 in hepatocellular carcinoma. OncoTargets and therapy, 5537-5544.

Wang, H., Tan, Z., Hu, H., Liu, H., Wu, T., Zheng, C., ... & Tu, J. (2019). microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1. BMC cancer, 19, 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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