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Mouse Anti-M. tuberculosis fbpC Recombinant Antibody (CBMC-C0133) (CBMAB-V208-0892-CQ)


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Summary

Host Animal
Mouse
Specificity
M. tuberculosis, M. smegmatis
Clone
CBMC-C0133
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Bacterial press extract from Mycobacterium tuberculosis H37Rv
Specificity
M. tuberculosis, M. smegmatis
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
15 mM Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.
Entrez Gene ID
886885
UniProt ID
P9WQN9
Alternative Names
fbpC; diacylglycerol acyltransferase/mycolyltransferase Ag85C; 85C; fbpC2; mpt45;
Function
The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.
Biological Process
Glycolipid biosynthetic processManual Assertion Based On ExperimentIDA:MTBBASE
Lipid transportManual Assertion Based On ExperimentIMP:MTBBASE
Mycolate cell wall layer assemblyManual Assertion Based On ExperimentIDA:MTBBASE
Response to antibioticManual Assertion Based On ExperimentIEP:MTBBASE
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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