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Mouse Anti-MAGEA11 (AA 1-319) Recombinant Antibody (CBFYM-1303) (CBMAB-M1462-FY)

This product is mouse antibody that recognizes MAGEA11. The antibody CBFYM-1303 can be used for immunoassay techniques such as: ELISA, WB.
See all MAGEA11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1303
Antibody Isotype
IgM, k
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MPLEQRSQHC KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF FSSTLNVGTL EELPAAESPS PPQSPQEESF SPTAMDAIFG SLSDEGSGSQ EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK GLITKAEMLG S
Specificity
Human
Antibody Isotype
IgM, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-319

Target

Full Name
MAGE Family Member A11
Introduction
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
4110
UniProt ID
P43364
Alternative Names
MAGE Family Member A11; MAGE-11 Antigen; Cancer/Testis Antigen Family 1, Member 11; Melanoma-Associated Antigen 11; Melanoma Antigen Family A11; Cancer/Testis Antigen 1.11
Function
Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
Biological Process
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm

Mohsenzadegan, M., Razmi, M., Vafaei, S., Abolhasani, M., Madjd, Z., Saeednejad Zanjani, L., & Sharifi, L. (2022). Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer. Scientific reports, 12(1), 599.

Tade, R. S., & Patil, P. O. (2022). Fabrication of poly (aspartic) acid functionalized graphene quantum dots based FRET sensor for selective and sensitive detection of MAGE-A11 antigen. Microchemical Journal, 183, 107971.

Kumar, N., Sood, D., Gupta, A., Jha, N. K., Jain, P., & Chandra, R. (2020). Cytotoxic T-lymphocyte elicited therapeutic vaccine candidate targeting cancer against MAGE-A11 carcinogenic protein. Bioscience Reports, 40(12), BSR20202349.

Jia, S., Zhang, M., Li, Y., Zhang, L., & Dai, W. (2020). MAGE-A11 expression predicts patient prognosis in head and neck squamous cell carcinoma. Cancer management and research, 1427-1435.

Wu, Y., Sang, M., Liu, F., Zhang, J., Li, W., Li, Z., ... & Shan, B. (2020). Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+ T cells against esophageal carcinoma. Carcinogenesis, 41(7), 894-903.

Su, S., Gu, Q., Xu, A., Shen, S., Liu, S., Zhang, C., ... & Wang, Z. (2019). Genetic variations in MAGE-A11 predict the risk and survival of renal cell cancer. Journal of Cancer, 10(20), 4860.

Gu, L., Sang, M., Li, J., Liu, F., Wu, Y., Liu, S., ... & Shan, B. (2019). Expression and prognostic significance of MAGE-A11 and transcription factors (SP1, TFCP2 and ZEB1) in ESCC tissues. Pathology-Research and Practice, 215(7), 152446.

Younas, K., Quintela, M., Thomas, S., Garcia-Parra, J., Blake, L., Whiteland, H., ... & Conlan, R. S. (2019). Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11. Journal of Molecular Medicine, 97, 1315-1327.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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