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Mouse Anti-MAGEA2 Recombinant Antibody (1B1) (CBMAB-A5156-LY)

The product is antibody recognizes MAGEA2. The antibody 1B1 immunoassay techniques such as: WB, ELISA.
See all MAGEA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MAGEA2 (AAH63681, 1 a.a. ~ 314 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
melanoma antigen family A, 2
Introduction
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
4101
UniProt ID
P43356
Alternative Names
MAGE2; MAGEA2A; MGC131923
Function
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Biological Process
Cellular protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular senescenceManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ubiquitin-protein transferase activityManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction by p53 class mediatorManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus, PML body
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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