Mouse Anti-MAN2C1 Recombinant Antibody (CBFYM-1365) (CBMAB-M1524-FY)

This product is mouse antibody that recognizes MAN2C1. The antibody CBFYM-1365 can be used for immunoassay techniques such as: ELISA.
See all MAN2C1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-1365

Antibody Isotype

IgM, k

Application

ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgM, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Antiserum

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MANNOSIDASE ALPHA CLASS 2C MEMBER 1

Introduction

MAN2C1 is a Protein Coding gene. Diseases associated with MAN2C1 include Pneumatosis Cystoides Intestinalis. Among its related pathways are Glycosaminoglycan metabolism and Other glycan degradation. Gene Ontology annotations related to this gene include carbohydrate binding and alpha-mannosidase activity.

Entrez Gene ID

4123

UniProt ID

Q9NTJ4

Alternative Names

Mannosidase Alpha Class 2C Member 1; Alpha-D-Mannoside Mannohydrolase; Alpha Mannosidase 6A8B; EC 3.2.1.24; MANA1; MANA; Mannosidase, Alpha, Class 2C, Member 1

Function

Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm.

Biological Process

Mannose metabolic processIEA:InterPro
Oligosaccharide catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

References

Maia, N., Potelle, S., Yildirim, H., Duvet, S., Akula, S. K., Schulz, C., ... & Foulquier, F. (2022). Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder. The American Journal of Human Genetics, 109(2), 345-360.

Kerkhove, L., Yildirim, H., Seneca, S., Gheldof, A., Dumitriu, D., Sermon, K., ... & Stouffs, K. (2020). The involvement of MAN2C1 in the development of cortical malformations.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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