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Mouse Anti-MAP1LC3B2 Recombinant Antibody (CBFYM-1392) (CBMAB-M1552-FY)

This product is mouse antibody that recognizes MAP1LC3B2. The antibody CBFYM-1392 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MAP1LC3B2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-1392
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA 2
Introduction
MAP1LC3B2 is a Protein Coding gene. Gene Ontology annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B.
Entrez Gene ID
Human643246
Rat100359928
UniProt ID
HumanA6NCE7
RatQ7TQ75
Alternative Names
Microtubule Associated Protein 1 Light Chain 3 Beta 2; Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like Protein; Microtubule-Associated Proteins 1A/1B Light Chain 3 Beta 2; Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like; ATG8G
Function
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Biological Process
Autophagosome assemblyManual Assertion Based On ExperimentIBA:GO_Central
Autophagosome maturationManual Assertion Based On ExperimentIBA:GO_Central
Autophagy of mitochondrionManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to nitrogen starvationManual Assertion Based On ExperimentIBA:GO_Central
MacroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, autophagosome membrane
Endomembrane system
Cytoplasm, cytoskeleton
PTM
The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, LC3-I (PubMed:30661429).
The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, LC3-II (By similarity).
During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity).
ATG4 proteins also mediate the delipidation of PE-conjugated forms (By similarity).
In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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