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Mouse Anti-MARS2 (AA 1-106) Recombinant Antibody (CBFYM-1734) (CBMAB-M1901-FY)

This product is mouse antibody that recognizes MARS2. The antibody CBFYM-1734 can be used for immunoassay techniques such as: ELISA, WB.
See all MARS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1734
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MLRTSVLRLL GRTGASRLSL LEDFGPRYYS SGSLSAGDDA CDVRAYFTTP IFYVNAAPHI GHLYSALLAD ALCRHRRLRG PSTAATRFST GTDEHGLKIQ QAAATA
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-106

Target

Full Name
methionyl-tRNA synthetase 2, mitochondrial
Introduction
This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3.
Entrez Gene ID
92935
UniProt ID
Q96GW9
Alternative Names
Methionyl-TRNA Synthetase 2, Mitochondrial; Methionine TRNA Ligase 2, Mitochondrial; EC 6.1.1.10; MtMetRS; Methionine-TRNA Synthetase 2, Mitochondrial; Mitochondrial Methionyl-TRNA Synthetase; Methionine--TRNA Ligase, Mitochondrial
Biological Process
Methionyl-tRNA aminoacylation Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome
Cellular Location
Mitochondrion
Mitochondrion matrix
Involvement in disease
Spastic ataxia 3, autosomal recessive (SPAX3):
A neurologic disorder characterized by cerebellar ataxia, ataxic gait, spasticity, and hyperreflexia. Other variable features include dysarthria, dysmetria, mild cognitive impairment, urinary urgency and dystonic positioning.
Combined oxidative phosphorylation deficiency 25 (COXPD25):
A mitochondrial disorder resulting in developmental delay, growth failure, and sensorineural hearing loss.

Son, J., Jung, O., Kim, J. H., Park, K. S., Kweon, H. S., Nguyen, N. T., ... & Lee, S. Y. (2023). MARS2 drives metabolic switch of non-small-cell lung cancer cells via interaction with MCU. Redox Biology, 60, 102628.

Lim, E., Waller, D., Lau, K., Steele, J., Pope, A., Ali, C., ... & Rogers, C. (2023). PL03. 10 MARS 2: A Multicentre Randomised Trial Comparing (Extended) Pleurectomy Decortication versus No Radical Surgery for Mesothelioma. Journal of Thoracic Oncology, 18(11), S36.

Gu, J., & Chu, K. (2021). Increased Mars2 expression upon microRNA‐4661‐5p‐mediated KDM5D downregulation is correlated with malignant degree of gastric cancer cells. Cell Biology International, 45(10), 2118-2128.

Lim, E., Darlison, L., Edwards, J., Elliott, D., Fennell, D. A., Popat, S., ... & Rogers, C. (2020). Protocol: Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma. BMJ Open, 10(9).

Lim, E., Darlison, L., Edwards, J., Elliott, D., Fennell, D. A., Popat, S., ... & Rogers, C. (2020). Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma. BMJ open, 10(9), e038892.

Warnock, C., Lord, K., Taylor, B., & Tod, A. (2019). Patient experiences of participation in a radical thoracic surgical trial: findings from the Mesothelioma and Radical Surgery Trial 2 (MARS 2). Trials, 20(1), 1-10.

Ma, P., Li, M., Lu, H., & Zhang, Z. (2019). MARS 2: A computational tool to resolve and extract features from large-scale GC-MS datasets. Chemometrics and Intelligent Laboratory Systems, 191, 12-20.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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