Mouse Anti-MARS2 (AA 1-106) Recombinant Antibody (CBFYM-1734) (CBMAB-M1901-FY)

Name: Mouse Anti-MARS2 (AA 1-106) Recombinant Antibody (CBFYM-1734)
SKU: CBMAB-M1901-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1734

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MLRTSVLRLL GRTGASRLSL LEDFGPRYYS SGSLSAGDDA CDVRAYFTTP IFYVNAAPHI GHLYSALLAD ALCRHRRLRG PSTAATRFST GTDEHGLKIQ QAAATA

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-106

More Infomation

Target

Full Name

methionyl-tRNA synthetase 2, mitochondrial

Introduction

This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3.

Entrez Gene ID

92935

UniProt ID

Q96GW9

Alternative Names

Methionyl-TRNA Synthetase 2, Mitochondrial; Methionine TRNA Ligase 2, Mitochondrial; EC 6.1.1.10; MtMetRS; Methionine-TRNA Synthetase 2, Mitochondrial; Mitochondrial Methionyl-TRNA Synthetase; Methionine--TRNA Ligase, Mitochondrial

Biological Process

Methionyl-tRNA aminoacylation Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome

Cellular Location

Mitochondrion
Mitochondrion matrix

Involvement in disease

Spastic ataxia 3, autosomal recessive (SPAX3):
A neurologic disorder characterized by cerebellar ataxia, ataxic gait, spasticity, and hyperreflexia. Other variable features include dysarthria, dysmetria, mild cognitive impairment, urinary urgency and dystonic positioning.
Combined oxidative phosphorylation deficiency 25 (COXPD25):
A mitochondrial disorder resulting in developmental delay, growth failure, and sensorineural hearing loss.

Son, J., Jung, O., Kim, J. H., Park, K. S., Kweon, H. S., Nguyen, N. T., ... & Lee, S. Y. (2023). MARS2 drives metabolic switch of non-small-cell lung cancer cells via interaction with MCU. Redox Biology, 60, 102628.

Lim, E., Waller, D., Lau, K., Steele, J., Pope, A., Ali, C., ... & Rogers, C. (2023). PL03. 10 MARS 2: A Multicentre Randomised Trial Comparing (Extended) Pleurectomy Decortication versus No Radical Surgery for Mesothelioma. Journal of Thoracic Oncology, 18(11), S36.

Gu, J., & Chu, K. (2021). Increased Mars2 expression upon microRNA‐4661‐5p‐mediated KDM5D downregulation is correlated with malignant degree of gastric cancer cells. Cell Biology International, 45(10), 2118-2128.

Lim, E., Darlison, L., Edwards, J., Elliott, D., Fennell, D. A., Popat, S., ... & Rogers, C. (2020). Protocol: Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma. BMJ Open, 10(9).

Lim, E., Darlison, L., Edwards, J., Elliott, D., Fennell, D. A., Popat, S., ... & Rogers, C. (2020). Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma. BMJ open, 10(9), e038892.

Warnock, C., Lord, K., Taylor, B., & Tod, A. (2019). Patient experiences of participation in a radical thoracic surgical trial: findings from the Mesothelioma and Radical Surgery Trial 2 (MARS 2). Trials, 20(1), 1-10.

Ma, P., Li, M., Lu, H., & Zhang, Z. (2019). MARS 2: A computational tool to resolve and extract features from large-scale GC-MS datasets. Chemometrics and Intelligent Laboratory Systems, 191, 12-20.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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