Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: ASTLQQLSFP VRAYKRLDGS TECCNNHSLT DVCFSYRNNF NKRLHTCLPA RKAVEATQVC RTNKDCKKSS SSSFCIIPSL ETHTRLIKVK HPPQIDMLYV GHPLHLH
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
Membrane Bound Transcription Factor Peptidase, Site 2; Sterol Regulatory Element-Binding Proteins Intramembrane Protease; Membrane-Bound Transcription Factor Protease, Site 2; Keratosis Follicularis Spinulosa Decalvans; SREBPs Intramembrane Protease; Endopeptidase S2P; Site-2 Protease; EC 184.108.40.206