Rabbit Anti-MC2R Recombinant Antibody (EG051) (CBMAB-EN058-LY)

Name: Rabbit Anti-MC2R Recombinant Antibody (EG051)
SKU: CBMAB-EN058-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG051

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human ACTHR.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Melanocortin 2 Receptor

Introduction

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]

Entrez Gene ID

Human	4158
Mouse	17200

UniProt ID

Human	Q01718
Mouse	Q64326

Alternative Names

Melanocortin 2 Receptor; Melanocortin 2 Receptor (Adrenocorticotropic Hormone); Adrenocorticotropic Hormone Receptor; Adrenocorticotropin Receptor; ACTH Receptor; ACTHR;

Function

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Regulation of metabolic process Source: GO_Central

Cellular Location

Cell membrane

Involvement in disease

Glucocorticoid deficiency 1 (GCCD1):
A form of glucocorticoid deficiency, a rare autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.

Topology

Extracellular: 1-23
Helical: 24-49
Cytoplasmic: 50-58
Helical: 59-79
Extracellular: 80-104
Helical: 105-126
Cytoplasmic: 127-147
Helical: 148-168
Extracellular: 169-180
Helical: 181-199
Cytoplasmic: 200-217
Helical: 218-244
Extracellular: 245-256
Helical: 257-278
Cytoplasmic: 279-297

Hoglin, B. E., Miner, M. V., Erdenebayar, U., Shaughnessy, C. A., & Dores, R. M. (2023). Trends in the evolution of the elasmobranch melanocortin-2 receptor: Insights from structure/function studies on the activation of whale shark Mc2r. General and Comparative Endocrinology, 338, 114278.

Luo, P., Feng, W., Ma, S., Dai, A., Wu, K., Chen, X., ... & Jiang, Y. (2023). Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Research, 33(1), 46-54.

Duan, Y., Xia, Y., Gong, Z., Liu, H., Liang, L., Zhang, K., ... & Qiu, W. (2023). A Novel Mutation in Melanocortin Receptor 2 and a Reported Mutation in Melanocortin Receptor 2 Accessory Protein: Three Chinese Cases with Familial Glucocorticoid Deficiency. Molecular Syndromology, 14(1), 71-79.

Shaughnessy, C. A., Jensen, M. F., & Dores, R. M. (2022). A basal actinopterygian melanocortin receptor: Molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus). General and Comparative Endocrinology, 328, 114105.

Dores, R. M., & Chapa, E. (2021). Hypothesis and Theory: Evaluating the co-evolution of the melanocortin-2 receptor and the accessory protein MRAP1. Frontiers in Endocrinology, 12, 747843.

Sato, T., Iwata, T., Usui, M., Kokabu, S., Sugamori, Y., Takaku, Y., ... & Chida, D. (2020). Bone phenotype in melanocortin 2 receptor-deficient mice. Bone Reports, 13, 100713.

Sandhu, N., Liang, L., McGeer, J., Dores, R. M., & Vijayan, M. M. (2019). Cadmium disrupts melanocortin 2 receptor signaling in rainbow trout. Aquatic Toxicology, 209, 26-33.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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