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Rabbit Anti-MC2R Recombinant Antibody (EG051) (CBMAB-EN058-LY)

The product is antibody recognizes MC2R . The antibody EG051 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000.
See all MC2R antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG051
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ACTHR.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Melanocortin 2 Receptor
Introduction
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
Entrez Gene ID
Human4158
Mouse17200
UniProt ID
HumanQ01718
MouseQ64326
Alternative Names
Melanocortin 2 Receptor; Melanocortin 2 Receptor (Adrenocorticotropic Hormone); Adrenocorticotropic Hormone Receptor; Adrenocorticotropin Receptor; ACTH Receptor; ACTHR;
Function
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Regulation of metabolic process Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
Glucocorticoid deficiency 1 (GCCD1):
A form of glucocorticoid deficiency, a rare autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.
Topology
Extracellular: 1-23
Helical: 24-49
Cytoplasmic: 50-58
Helical: 59-79
Extracellular: 80-104
Helical: 105-126
Cytoplasmic: 127-147
Helical: 148-168
Extracellular: 169-180
Helical: 181-199
Cytoplasmic: 200-217
Helical: 218-244
Extracellular: 245-256
Helical: 257-278
Cytoplasmic: 279-297

Hoglin, B. E., Miner, M. V., Erdenebayar, U., Shaughnessy, C. A., & Dores, R. M. (2023). Trends in the evolution of the elasmobranch melanocortin-2 receptor: Insights from structure/function studies on the activation of whale shark Mc2r. General and Comparative Endocrinology, 338, 114278.

Luo, P., Feng, W., Ma, S., Dai, A., Wu, K., Chen, X., ... & Jiang, Y. (2023). Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Research, 33(1), 46-54.

Duan, Y., Xia, Y., Gong, Z., Liu, H., Liang, L., Zhang, K., ... & Qiu, W. (2023). A Novel Mutation in Melanocortin Receptor 2 and a Reported Mutation in Melanocortin Receptor 2 Accessory Protein: Three Chinese Cases with Familial Glucocorticoid Deficiency. Molecular Syndromology, 14(1), 71-79.

Shaughnessy, C. A., Jensen, M. F., & Dores, R. M. (2022). A basal actinopterygian melanocortin receptor: Molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus). General and Comparative Endocrinology, 328, 114105.

Dores, R. M., & Chapa, E. (2021). Hypothesis and Theory: Evaluating the co-evolution of the melanocortin-2 receptor and the accessory protein MRAP1. Frontiers in Endocrinology, 12, 747843.

Sato, T., Iwata, T., Usui, M., Kokabu, S., Sugamori, Y., Takaku, Y., ... & Chida, D. (2020). Bone phenotype in melanocortin 2 receptor-deficient mice. Bone Reports, 13, 100713.

Sandhu, N., Liang, L., McGeer, J., Dores, R. M., & Vijayan, M. M. (2019). Cadmium disrupts melanocortin 2 receptor signaling in rainbow trout. Aquatic Toxicology, 209, 26-33.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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