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Rabbit Anti-MCRIP1 Recombinant Antibody (D2Y8V) (CBMAB-CP0673-LY)

The product is antibody recognizes MCRIP1. The antibody D2Y8V immunoassay techniques such as: WB,IP.
See all MCRIP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D2Y8V
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro56 of human MCRIP1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAPK Regulated Corepressor Interacting Protein 1
Introduction
MCRIP1 (MAPK Regulated Corepressor Interacting Protein 1) is a Protein Coding gene. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is MCRIP2.
Entrez Gene ID
348262
UniProt ID
C9JLW8
Alternative Names
MAPK Regulated Corepressor Interacting Protein 1; Granulin-2; Family With Sequence Similarity 195; Member B; Protein FAM195B; FAM195B; GRAN2;
Function
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).
Biological Process
Regulation of epithelial to mesenchymal transition Source: UniProtKB
Cellular Location
Nucleus
Other locations
Stress granule
PTM
Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s) (PubMed:25728771).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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