Rabbit Anti-MCRIP1 Recombinant Antibody (D2Y8V) (CBMAB-CP0673-LY)

Name: Rabbit Anti-MCRIP1 Recombinant Antibody (D2Y8V)
SKU: CBMAB-CP0673-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D2Y8V

Application

WB, IP

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro56 of human MCRIP1 protein.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MAPK Regulated Corepressor Interacting Protein 1

Introduction

MCRIP1 (MAPK Regulated Corepressor Interacting Protein 1) is a Protein Coding gene. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is MCRIP2.

Entrez Gene ID

348262

UniProt ID

C9JLW8

Alternative Names

MAPK Regulated Corepressor Interacting Protein 1; Granulin-2; Family With Sequence Similarity 195; Member B; Protein FAM195B; FAM195B; GRAN2;

Function

The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).

Biological Process

Regulation of epithelial to mesenchymal transition Source: UniProtKB

Cellular Location

Nucleus
Other locations
Stress granule

PTM

Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s) (PubMed:25728771).

Weng, J. S., Nakamura, T., Moriizumi, H., Takano, H., Yao, R., & Takekawa, M. (2019). MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing. Communications biology, 2(1), 227.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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