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Mouse Anti-MED13 Recombinant Antibody (CBYJT-1462) (CBMAB-T0493-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to MED13 (Mediator Complex Subunit 13). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all MED13 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-1462
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 476-775 mapping within an internal region of TRAP240 of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 476-775

Target

Full Name
Mediator Complex Subunit 13
Introduction
MED13 is a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. MED13 is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.
Entrez Gene ID
Human9969
Mouse327987
Rat303403
UniProt ID
HumanQ9UHV7
MouseQ5SWW4
RatF1LXU0
Alternative Names
Mediator Complex Subunit 13; Thyroid Hormone Receptor-Associated Protein Complex 240 KDa Component; Vitamin D3 Receptor-Interacting Protein Complex Component DRIP250; Activator-Recruited Cofactor 250 KDa Component; Thyroid Hormone Receptor-Associated Protein 1; DRIP250; TRAP240; THRAP1; ARC250
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Biological Process
Cholesterol homeostasis Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Triglyceride homeostasis Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Intellectual developmental disorder, autosomal dominant 61 (MRD61):
An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD61 is characterized by global developmental delay apparent in infancy with mildly impaired intellectual development, expressive speech delay, and behavioral abnormalities, including autism spectrum disorder and attention deficit-hyperactivity disorder. Additional features are highly variable and may include non-specific dysmorphic features, obstipation, ocular anomalies, and poor overall growth.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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