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Mouse Anti-MED14 Recombinant Antibody (8C80) (CBMAB-C3929-CN)

This product is a Mouse antibody that recognizes MED14. The antibody 8C80 can be used for immunoassay techniques such as: Dot, WB.
See all MED14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8C80
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Immunogen
Partial sequence of recombinant full-length human CRSP2 protein (PASFVPTPPP SSHGISIGPG ASFASPHGTL DPSSPYTMVS PSGRAGNWPG SPQVSGPSPA ARMPGMSPAN PSLHSPVPDA SHSPRAGTSS QTMPTNMPPP RKLPQRSW)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL

Target

Full Name
Mediator Complex Subunit 14
Introduction
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
9282
UniProt ID
O60244
Alternative Names
Mediator Complex Subunit 14; Thyroid Hormone Receptor-Associated Protein Complex 170 KDa Component; Vitamin D3 Receptor-Interacting Protein Complex 150 KDa Component; Activator-Recruited Cofactor 150 KDa Component; CRSP Complex Subunit 2; RGR1 Homolog; DRIP150; TRAP170; CXorf4; ARC150; CRSP2; EXLM1; HRGR1;
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Biological Process
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: MGI
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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