Mouse Anti-MED31 (AA 1-131) Recombinant Antibody (CBFYM-2010) (CBMAB-M2188-FY)

Name: Mouse Anti-MED31 (AA 1-131) Recombinant Antibody (CBFYM-2010)
SKU: CBMAB-M2188-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2010

Application

ELISA, WB

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN YLKYLLYWKD PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ QILHWQHYSR KRMRLQQALA EQQQQNNTSG K

Specificity

Human

Antibody Isotype

IgG2b, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-131

More Infomation

Target

Full Name

MEDIATOR COMPLEX SUBUNIT 31

Introduction

MED31 is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha. Gene Ontology annotations related to this gene include protein complex binding and RNA polymerase II transcription cofactor activity.

Entrez Gene ID

51003

UniProt ID

Q9Y3C7

Alternative Names

Mediator Complex Subunit 31; Mediator Complex Subunit SOH1; HSOH1; Soh1; Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog (S. Cerevisiae); Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog; Mediator Of RNA Polymerase II Transcription Subunit 31; 3110004H13Rik; CGI-125

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Biological Process

Limb development Source: Ensembl
Negative regulation of fibroblast proliferation Source: Ensembl
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: ComplexPortal

Cellular Location

Nucleus

Garg, J., Saettone, A., Nabeel-Shah, S., Cadorin, M., Ponce, M., Marquez, S., ... & Fillingham, J. (2019). The Med31 conserved component of the divergent mediator complex in Tetrahymena thermophila participates in developmental regulation. Current Biology, 29(14), 2371-2379.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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