Mouse Anti-MEGF8 Recombinant Antibody (CBFYM-2039) (CBMAB-M2219-FY)

Name: Mouse Anti-MEGF8 Recombinant Antibody (CBFYM-2039)
SKU: CBMAB-M2219-FY
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBFYM-2039

Application

WB, ICC

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.19 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MULTIPLE EGF LIKE DOMAINS 8

Introduction

The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

1954

UniProt ID

Q7Z7M0

Alternative Names

Multiple EGF Like Domains 8; Epidermal Growth Factor-Like Protein 4; EGF-Like-Domain, Multiple 4; C19orf49; EGFL4; Multiple Epidermal Growth Factor-Like Domains Protein 8; Hepatitis B Virus Pre-S2-Binding Protein 1; EGF-Like Domain-Containing Protein 4; Chromosome 19 Open Reading Frame 49; Multiple EGF-Like Domains Protein 8

Function

Acts as a negative regulator of hedgehog signaling.

Biological Process

Animal organ morphogenesis Source: GO_Central
BMP signaling pathway Source: CAFA
Cell migration involved in gastrulation Source: UniProtKB
Coronary vasculature development Source: Ensembl
Craniofacial suture morphogenesis Source: UniProtKB
Determination of digestive tract left/right asymmetry Source: UniProtKB
Determination of heart left/right asymmetry Source: UniProtKB
Embryonic heart tube left/right pattern formation Source: CAFA
Embryonic heart tube morphogenesis Source: CAFA
Embryonic limb morphogenesis Source: CAFA
Embryonic skeletal system morphogenesis Source: CAFA
Epiboly involved in gastrulation with mouth forming second Source: UniProtKB
Fasciculation of sensory neuron axon Source: CAFA
Left/right pattern formation Source: UniProtKB
Limb morphogenesis Source: UniProtKB
Negative regulation of smoothened signaling pathway Source: UniProtKB
Positive regulation of axon extension involved in axon guidance Source: CAFA
Regulation of gene expression Source: CAFA
Tissue development Source: GO_Central

Cellular Location

Membrane

Involvement in disease

Carpenter syndrome 2 (CRPT2):
An autosomal recessive multiple congenital malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet, in association with abnormal left-right patterning and other features, most commonly obesity, umbilical hernia, cryptorchidism, and congenital heart disease.

Topology

Extracellular: 28-2647
Helical: 2648-2668
Cytoplasmic: 2669-2845

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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