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Mouse Anti-MEGF8 Recombinant Antibody (CBFYM-2039) (CBMAB-M2219-FY)

This product is mouse antibody that recognizes MEGF8. The antibody CBFYM-2039 can be used for immunoassay techniques such as: WB, ICC.
See all MEGF8 antibodies
Published Data
Fig.1 Distribution of Megf8 in embryos and cultured cells.
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Fig.2 Distribution of Megf8 in embryos and cultured cells.
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Fig.3 Distribution of Megf8 in embryos and cultured cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2039
Antibody Isotype
IgG2b
Application
WB, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.19 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MULTIPLE EGF LIKE DOMAINS 8
Introduction
The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
1954
UniProt ID
Q7Z7M0
Alternative Names
Multiple EGF Like Domains 8; Epidermal Growth Factor-Like Protein 4; EGF-Like-Domain, Multiple 4; C19orf49; EGFL4; Multiple Epidermal Growth Factor-Like Domains Protein 8; Hepatitis B Virus Pre-S2-Binding Protein 1; EGF-Like Domain-Containing Protein 4; Chromosome 19 Open Reading Frame 49; Multiple EGF-Like Domains Protein 8
Function
Acts as a negative regulator of hedgehog signaling.
Biological Process
Animal organ morphogenesis Source: GO_Central
BMP signaling pathway Source: CAFA
Cell migration involved in gastrulation Source: UniProtKB
Coronary vasculature development Source: Ensembl
Craniofacial suture morphogenesis Source: UniProtKB
Determination of digestive tract left/right asymmetry Source: UniProtKB
Determination of heart left/right asymmetry Source: UniProtKB
Embryonic heart tube left/right pattern formation Source: CAFA
Embryonic heart tube morphogenesis Source: CAFA
Embryonic limb morphogenesis Source: CAFA
Embryonic skeletal system morphogenesis Source: CAFA
Epiboly involved in gastrulation with mouth forming second Source: UniProtKB
Fasciculation of sensory neuron axon Source: CAFA
Left/right pattern formation Source: UniProtKB
Limb morphogenesis Source: UniProtKB
Negative regulation of smoothened signaling pathway Source: UniProtKB
Positive regulation of axon extension involved in axon guidance Source: CAFA
Regulation of gene expression Source: CAFA
Tissue development Source: GO_Central
Cellular Location
Membrane
Involvement in disease
Carpenter syndrome 2 (CRPT2):
An autosomal recessive multiple congenital malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet, in association with abnormal left-right patterning and other features, most commonly obesity, umbilical hernia, cryptorchidism, and congenital heart disease.
Topology
Extracellular: 28-2647
Helical: 2648-2668
Cytoplasmic: 2669-2845
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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