Mouse Anti-MEI1 Recombinant Antibody (CBFYM-2040) (CBMAB-M2220-FY)

This product is mouse antibody that recognizes MEI1. The antibody CBFYM-2040 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MEI1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2040

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MEIOTIC DOUBLE-STRANDED BREAK FORMATION PROTEIN 1

Introduction

MEI1 is a Protein Coding gene. Diseases associated with MEI1 include Aggressive Systemic Mastocytosis. Gene Ontology annotations related to this gene include binding.

Entrez Gene ID

150365

UniProt ID

Q5TIA1

Alternative Names

Meiotic Double-Stranded Break Formation Protein 1; Spermatogenesis Associated 38; Meiosis Defective Protein 1; Meiosis Inhibitor 1; Meiosis Inhibitor Protein 1; Meiosis Defective 1; SPATA38

Function

Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).

Biological Process

Meiosis I Source: GO_Central

Cellular Location

Hydatidiform mole, recurrent, 3 (HYDM3):
A disorder characterized by excessive trophoblast development that produces a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi.

References

Zhang, Y., Li, N., Ji, Z., Bai, H., Ou, N., Tian, R., ... & Yao, C. (2023). Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermia. Journal of Human Genetics, 68(6), 383-392.

Chen, J., Li, F. H., Xing, J. H., Zhang, X. B., Du, Z. L., Jin, Y. S., ... & Wang, X. (2023). Novel MEI1 compound heterozygous mutation in a sporadic family associated with spermatogenetic failure. Asian Journal of Andrology, 25(4), 544-546.

Dong, J., Zhang, H., Mao, X., Zhu, J., Li, D., Fu, J., ... & Sang, Q. (2021). Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure. Human Reproduction, 36(8), 2371-2381.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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