Sign in or Register   Sign in or Register
  |  

Rat Anti-MEP1B (AA 23-293) Recombinant Antibody (CBFYM-2076) (CBMAB-M2257-FY)

This product is rat antibody that recognizes MEP1B. The antibody CBFYM-2076 can be used for immunoassay techniques such as: WB, IHC.
See all MEP1B antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
CBFYM-2076
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human embryonic kidney cell line HEK293-derived recombinant human Meprin beta Subunit/MEP1B, Thr23-Ser293
Specificity
Human, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 23-293

Target

Full Name
MEPRIN A SUBUNIT BETA
Introduction
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
Entrez Gene ID
Human4225
Mouse17288
UniProt ID
HumanQ16820
MouseQ61847
Alternative Names
Meprin A Subunit Beta; N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta; PABA Peptide Hydrolase; Endopeptidase-2; Meprin A, Beta; Meprin B; PPH Beta; N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Beta Subunit; EC 3.4.24.63
Function
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
Biological Process
Inflammatory response Source: UniProtKB-KW
Toxin transport Source: Ensembl
Cellular Location
Secreted
Plasma membrane
Cell membrane
Note: Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
Topology
Extracellular: 23-652
Helical: 653-673
Cytoplasmic: 674-701
PTM
N-glycosylated; contains high mannose and/or complex biantennary structures.
O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.
Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-MEP1B (AA 23-293) Recombinant Antibody (CBFYM-2076)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare