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Mouse Anti-MEST Recombinant Antibody (CF285) (CBMAB-FT227LY)

The product is antibody recognizes MEST . The antibody CF285 immunoassay techniques such as: ELISA, WB, IF, IHC.
See all MEST antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CF285
Antibody Isotype
IgG2a
Application
ELISA, WB, IF, IHC

Basic Information

Immunogen
mesoderm specific transcript homolog (Mouse)
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mesoderm Specific Transcript
Introduction
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Entrez Gene ID
Human4232
Mouse17294
UniProt ID
HumanQ5EB52
MouseQ07646
Alternative Names
PEG1
Biological Process
Mesoderm development Source: ProtInc
Regulation of lipid storage Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane

Wang, H., Cui, X., Wang, L., Fan, N., Yu, M., Qin, H., ... & Yan, Q. (2023). α1, 3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation. Cell Death & Disease, 14(10), 651.

Amjadian, T., Yaghmaei, P., Nasim, H. R., & Yari, K. (2023). Impact of DNA methylation of the human mesoderm-specific transcript (MEST) on male infertility. Heliyon, 9(10).

Cannarella, R., Leanza, C., Crafa, A., Barbagallo, F., La Vignera, S., Condorelli, R. A. A., ... & Calogero, A. E. (2023). Sperm Mesoderm Specific Transcript Gene Methylation Status in Infertile Patients: A Systematic Review and Meta-Analysis. Fertility and Sterility, 120(4), e29.

Kadota, Y., Kawakami, T., Sato, M., & Suzuki, S. (2022). Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes. BMC Research Notes, 15(1), 164.

Anunciado-Koza, R. P., Stohn, J. P., Hernandez, A., & Koza, R. A. (2022). Social and maternal behavior in mesoderm specific transcript (Mest)-deficient mice. PloS one, 17(7), e0271913.

Pan, Y., Wang, X., Li, Y., Yan, P., & Zhang, H. (2022). Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST. Cancer Gene Therapy, 29(8-9), 1130-1139.

Yin, L., & Wang, Y. (2021). Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis. Cancer cell international, 21, 1-15.

Wang, Y., Zhang, J., Li, Y. J., Yu, N. N., Liu, W. T., Liang, J. Z., ... & He, Q. Y. (2021). MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling. Journal of Experimental & Clinical Cancer Research, 40(1), 1-20.

Prasad, R., Jung, H., Tan, A., Song, Y., Moon, S., Shaker, M. R., ... & Jho, E. H. (2021). Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer’s disease. Scientific reports, 11(1), 20075.

Ruan, Z., & Zhao, D. (2019). Long intergenic noncoding RNA LINC00284 knockdown reduces angiogenesis in ovarian cancer cells via up-regulation of MEST through NF-κB1. The FASEB Journal, 33(11), 12047.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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