Mouse Anti-METTL6 Recombinant Antibody (CBFYM-2130) (CBMAB-M2312-FY)

Name: Mouse Anti-METTL6 Recombinant Antibody (CBFYM-2130)
SKU: CBMAB-M2312-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2130

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

METHYLTRANSFERASE LIKE 6

Introduction

METTL6 is a Protein Coding gene. Gene Ontology annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

Entrez Gene ID

Human	131965
Mouse	67011
Rat	290564

UniProt ID

Human	Q8TCB7
Mouse	Q8BVH9
Rat	Q6AXU8

Alternative Names

Methyltransferase Like 6; EC 2.1.1.41; EC 2.1.1.-; EC 2.1.1

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34922197, PubMed:34268557, PubMed:34862464).

Interaction with SARS1/SerRS is required for N3-methylcytidine methylation (PubMed:34268557).

Biological Process

tRNA methylation Source: UniProtKB

Cellular Location

Nucleus
Cytoplasm

Throll, P., Dolce, L. G., Lastres, P. R., Arnold, K., Tengo, L., Basu, S., ... & Kowalinski, E. (2023). Structural basis of tRNA recognition by the m3C-RNA-methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase. bioRxiv, 2023-12.

Bolatkan, A., Asada, K., Kaneko, S., Suvarna, K., Ikawa, N., Machino, H., ... & Hamamoto, R. (2022). Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. International Journal of Oncology, 60(1), 1-13.

Li, S., Zhou, H., Liao, S., Wang, X., Zhu, Z., Zhang, J., & Xu, C. (2022). Structural basis for METTL6-mediated m3C RNA methylation. Biochemical and Biophysical Research Communications, 589, 159-164.

Mao, X. L., Li, Z. H., Huang, M. H., Wang, J. T., Zhou, J. B., Li, Q. R., ... & Zhou, X. L. (2021). Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6. Nucleic Acids Research, 49(14), 8309-8323.

Chen, R., Zhou, J., Liu, L., Mao, X. L., Zhou, X., & Xie, W. (2021). Crystal structure of human METTL6, the m3C methyltransferase. Communications biology, 4(1), 1361.

Ignatova, V. V., Kaiser, S., Ho, J. S. Y., Bing, X., Stolz, P., Tan, Y. X., ... & Schneider, R. (2020). METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. Science advances, 6(35), eaaz4551.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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