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Mouse Anti-METTL7A (AA 34-104) Recombinant Antibody (CBFYM-2131) (CBMAB-M2313-FY)

This product is mouse antibody that recognizes METTL7A. The antibody CBFYM-2131 can be used for immunoassay techniques such as: WB, IHC.
See all METTL7A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2131
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Recombinant protein fragment corresponding to amino acids 34-104 of human METTL7A(NP_054752) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 34-104

Target

Full Name
METHYLTRANSFERASE LIKE 7A
Introduction
METTL7A is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7B.
Entrez Gene ID
25840
UniProt ID
Q9H8H3
Alternative Names
Methyltransferase Like 7A; Protein AAM-B; Methyltransferase-Like Protein 7A; EC 2.1.1.-; EC 2.1.1; AAM-B
Function
Putative methyltransferase.

(Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
Biological Process
Methylation Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum
Other locations
Lipid droplet
Membrane
Note: Inserted in the ER membrane and migrates from the inserted site to lipid droplet.

Robey, R. W., Fitzsimmons, C. M., Guiblet, W. M., Frye, W. J., González Dalmasy, J. M., Wang, L., ... & Batista, P. J. (2023). The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors. Molecular Cancer Therapeutics.

Liu, Z., Chen, Y., & Shen, T. (2023). Evidence based on an integrative analysis of multi-omics data on mettl7a as a molecular marker in pan-cancer. Biomolecules, 13(2), 195.

Russell, D. A., Chau, M. K., Shi, Y., Levasseur, I. N., Maldonato, B. J., & Totah, R. A. (2023). METTL7A (TMT1A) and METTL7B (TMT1B) are responsible for alkyl s-thiol methyl transferase activity in liver. Drug Metabolism and Disposition, 51(8), 1024-1034.

González Dalmasy, J. M., Fitzsimmons, C., Frye, W. J., Perciaccante, A. J., Jewell, C. P., Jenkins, L. M., ... & Gottesman, M. M. (2023). The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species. bioRxiv, 2023-11.

Yang, Z., Zhang, W., Li, L., Hu, N., Dong, X., Chen, Y., ... & Dai, Y. (2023). The novel putative methyltransferase METTL7A as one prognostic biomarker potentially associated with immune infiltration in human renal cancer. Heliyon, 9(4).

Vera-Montecinos, A., Galiano-Landeira, J., Roldán, M., Vidal-Domènech, F., Claro, E., & Ramos, B. (2023). A Novel Localization of METTL7A in Bergmann Glial Cells in Human Cerebellum. International journal of molecular sciences, 24(9), 8405.

Pan, Y. Q., Xiao, Y., Li, Z., Tao, L., Chen, G., Zhu, J. F., ... & Shao, A. (2022). Comprehensive analysis of the significance of METTL7A gene in the prognosis of lung adenocarcinoma. Frontiers in Oncology, 12, 1071100.

Russell, D. A., Chau, M. K., Shi, Y., Maldonato, B. J., & Totah, R. A. (2022). METTL7A and METTL7B are responsible for S-thiol methyl transferase activity in liver. bioRxiv, 2022-10.

Lee, E., Kim, J. Y., Kim, T. K., Park, S. Y., & Im, G. I. (2021). Methyltransferase-like protein 7A (METTL7A) promotes cell survival and osteogenic differentiation under metabolic stress. Cell death discovery, 7(1), 154.

Wang, N., Han, X., Yang, H., Xia, D., & Fan, Z. (2021). miR-6807-5p Inhibited the odontogenic differentiation of human dental pulp stem cells through directly targeting METTL7A. Frontiers in cell and developmental biology, 9, 759192.

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For research use only. Not intended for any clinical use.

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