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Mouse Anti-METTL7B Recombinant Antibody (CBFYM-2133) (CBMAB-M2315-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2133
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
METHYLTRANSFERASE LIKE 7B
Introduction
METTL7B is a Protein Coding gene. Gene Ontology annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7A.
Entrez Gene ID
196410
UniProt ID
Q6UX53
Alternative Names
Methyltransferase Like 7B; Associated With Lipid Droplets 1; Methyltransferase-Like Protein 7B; EC 2.1.1.-; EC 2.1.1; ALDI
Function
Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to hydrogen sulfide and other thiol compounds including dithiothreitol, 7alpha-thiospironolactone, L-penicillamine, and captopril.
Biological Process
Methylation Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane
Other locations
Lipid droplet
Note: Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets. May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form.
More Infomation

Russell, D. A., Chau, M. K., Shi, Y., Levasseur, I. N., Maldonato, B. J., & Totah, R. A. (2023). METTL7A (TMT1A) and METTL7B (TMT1B) are responsible for alkyl s-thiol methyl transferase activity in liver. Drug Metabolism and Disposition, 51(8), 1024-1034.

Fu, R., Luo, X., Ding, Y., & Guo, S. (2022). Prognostic potential of METTL7B in glioma. Neuroimmunomodulation, 29(3), 186-201.

Li, R., Mu, C., Cao, Y., & Fan, Y. (2022). METTL7B serves as a prognostic biomarker and promotes metastasis of lung adenocarcinoma cells. Annals of Translational Medicine, 10(16).

Russell, D. A., Chau, M. K., Shi, Y., Maldonato, B. J., & Totah, R. A. (2022). METTL7A and METTL7B are responsible for S-thiol methyl transferase activity in liver. bioRxiv, 2022-10.

Li, W., Xu, S., Peng, N., Zhang, Z., He, H., Chen, R., ... & Wang, X. (2021). Downregulation of METTL7B inhibits proliferation of human clear cell renal cancer cells in vivo and in vitro. Frontiers in oncology, 11, 634542.

Maldonato, B. J., Russell, D. A., & Totah, R. A. (2021). Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril. Scientific reports, 11(1), 4857.

Xiong, Y., Li, M., Bai, J., Sheng, Y., & Zhang, Y. (2021). High level of METTL7B indicates poor prognosis of patients and is related to immunity in glioma. Frontiers in oncology, 11, 650534.

Jiang, Z., Yin, W., Zhu, H., Tan, J., Guo, Y., Xin, Z., ... & Ren, C. (2021). METTL7B is a novel prognostic biomarker of lower-grade glioma based on pan-cancer analysis. Cancer Cell International, 21, 1-16.

Liu, D., Li, W., Zhong, F., Yin, J., Zhou, W., Li, S., ... & Zou, C. (2020). METTL7B is required for cancer cell proliferation and tumorigenesis in non-small cell lung cancer. Frontiers in pharmacology, 11, 178.

Ali, J., Liu, W., Duan, W., Liu, C., Song, J., Ali, S., ... & Wang, Q. (2020). METTL7B (methyltransferase-like 7B) identification as a novel biomarker for lung adenocarcinoma. Annals of translational medicine, 8(18).

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For research use only. Not intended for any clinical use.

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