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Mouse Anti-MGA Recombinant Antibody (CBFYM-2162) (CBMAB-M2344-FY)

This product is mouse antibody that recognizes MGA. The antibody CBFYM-2162 can be used for immunoassay techniques such as: WB.
See all MGA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2162
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant human MAX Gene Associated
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MGA, MAX DIMERIZATION PROTEIN
Introduction
MGA is a Protein Coding gene. Diseases associated with MGA include Aicardi-Goutieres Syndrome. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is TBR1.
Entrez Gene ID
23269
UniProt ID
Q8IWI9
Alternative Names
MGA, MAX Dimerization Protein; MAX Dimerization Protein 5; MAD5; MAX Gene-Associated Protein; MAX Gene Associated; KIAA0518; MXD5
Function
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).
Biological Process
Cell fate specification Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Wangsiricharoen, S., Wakely Jr, P. E., Prieto, V. G., & Yu, W. (2023). Sarcoma with MGA:: NUTM1 fusion: a report of three cases and literature review. Histopathology, 83(5), 712-721.

Zhu, J. Y., Wang, G., Huang, X., Lee, H., Lee, J. G., Yang, P., ... & Han, Z. (2022). SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis. Communications biology, 5(1), 1039.

Llabata, P., Torres-Diz, M., Gomez, A., Tomas-Daza, L., Romero, O. A., Grego-Bessa, J., ... & Sanchez-Cespedes, M. (2021). MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex. Proceedings of the National Academy of Sciences, 118(37), e2024824118.

Mathsyaraja, H., Catchpole, J., Freie, B., Eastwood, E., Babaeva, E., Geuenich, M., ... & Eisenman, R. N. (2021). Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness. Elife, 10, e64212.

Goto, T., Arai, Y., Shibata, T., Oyama, T., & Yoshida, A. (2020). Sarcoma with MGA–NUTM1 fusion in the lung: an emerging entity. Virchows Archiv, 476, 317-322.

Llabata, P., Mitsuishi, Y., Choi, P. S., Cai, D., Francis, J. M., Torres-Diz, M., ... & Zhang, X. (2020). Multi-omics analysis identifies MGA as a negative regulator of the MYC pathway in lung adenocarcinoma. Molecular Cancer Research, 18(4), 574-584.

Mathsyaraja, H., Catchpole, J., Eastwood, E., Babaeva, E., Geuenich, M., Cheng, P. F., ... & Eisenman, R. N. (2020). Loss of MGA mediated Polycomb repression promotes tumor progression and invasiveness. bioRxiv, 2020-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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