Mouse Anti-MGAT4A (AA 436-536) Recombinant Antibody (CBFYM-0494) (CBMAB-M0622-FY)

Name: Mouse Anti-MGAT4A (AA 436-536) Recombinant Antibody (CBFYM-0494)
SKU: CBMAB-M0622-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0494

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 436-536

More Infomation

Target

Full Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

Introduction

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.

Entrez Gene ID

11320

UniProt ID

Q9UM21

Alternative Names

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A; UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IVa; Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isoenzyme A; N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVa; N-Acetylglucosaminyltransferase IVa; GlcNAc-T IVa; EC 2.4.1.145; GNT-IVA

Function

Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639).

Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).

Biological Process

Glyoxylate metabolic process Source: UniProtKB
N-glycan processing Source: UniProtKB
Positive regulation of protein glycosylation in Golgi Source: UniProtKB
Protein N-linked glycosylation Source: GO_Central
Viral protein processing Source: Reactome

Cellular Location

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A:
Golgi apparatus
Golgi apparatus membrane
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form:
Secreted

Topology

Cytoplasmic: 1-4
Helical: 5-27
Lumenal: 28-535

PTM

N-glycosylated.

Maeda, K., & Taniguchi, N. (2023). Enzyme assay of N-acetylglucosaminyltransferase-IV (GnT-IVa, b, MGAT4A, B).

Nagae, M., Hirata, T., Tateno, H., Mishra, S. K., Manabe, N., Osada, N., ... & Kizuka, Y. (2022). Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A). Communications Biology, 5(1), 695.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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