Mouse Anti-MIEF2 Recombinant Antibody (CBXS-2026) (CBMAB-S4793-CQ)

Name: Mouse Anti-MIEF2 Recombinant Antibody (CBXS-2026)
SKU: CBMAB-S4793-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2026

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mitochondrial Elongation Factor 2

Introduction

This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

Mouse	237781
Rat	497916

UniProt ID

Mouse	Q5NCS9
Rat	D3ZS35

Alternative Names

AI482195; Gm11; Smcr7

Function

Mitochondrial outer membrane protein involved in the regulation of mitochondrial organization (PubMed:29361167).

It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.

Biological Process

Dynamin family protein polymerization involved in mitochondrial fission Source: UniProtKB
Mitochondrion organization Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of protein targeting to membrane Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB

Cellular Location

Mitochondrion
Mitochondrion outer membrane
Note: Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.

Involvement in disease

Combined oxidative phosphorylation deficiency 49 (COXPD49):
An autosomal recessive, mitochondrial myopathy characterized by progressive muscle weakness, intermittent muscle pain, exercise intolerance, elevated serum creatine kinase, and deficiencies of multiple respiratory chain enzymes.

Topology

Mitochondrial intermembrane: 1-22
Helical: 23-43
Cytoplasmic: 44-454

Xie, C., Li, K., Li, Y., Peng, X., Teng, B., He, K., ... & Wei, Z. (2022). CRISPR-based knockout screening identifies the loss of MIEF2 to enhance oxaliplatin resistance in colorectal cancer through inhibiting the mitochondrial apoptosis pathway. Frontiers in Oncology, 12, 881487.

Zhao, S., Cheng, L., Shi, Y., Li, J., Yun, Q., & Yang, H. (2021). MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway. Cell death & disease, 12(1), 18.

Zhao, S., Zhang, X., Shi, Y., Cheng, L., Song, T., Wu, B., ... & Yang, H. (2020). MIEF2 over-expression promotes tumor growth and metastasis through reprogramming of glucose metabolism in ovarian cancer. Journal of Experimental & Clinical Cancer Research, 39, 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-MIEF2 Recombinant Antibody (CBXS-2781) (CAT#: CBMAB-S5532-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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