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Mouse Anti-MIEN1 Recombinant Antibody (CBXC-2228) (CBMAB-C3490-CQ)

This product is a mouse antibody that recognizes MIEN1. The antibody CBXC-2228 can be used for immunoassay techniques such as: WB.
See all MIEN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2228
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human C17orf37(NP_115715) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Migration And Invasion Enhancer 1
Introduction
MIEN1 (Migration And Invasion Enhancer 1) is a Protein Coding gene, and is affiliated with the antisense RNA class. Gene Ontology (GO) annotations related to this gene include selenium binding.
Entrez Gene ID
UniProt ID
Alternative Names
Migration And Invasion Enhancer 1; HBV X-Transactivated Gene 4 Protein; HBV XAg-Transactivated Protein 4; C17orf37; RDX12; XTP4;
Function
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Response to selenium ion Source: GO_Central
Cellular Location
Cytosol
Plasma membrane
Cell membrane
Note: Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
PTM
Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.

Cheng, L., Shi, H., Du, L., Liu, Q., Yue, H., Zhang, H., ... & Shen, Y. (2024). Hemodynamic force dictates endothelial angiogenesis through MIEN1‐ERK/MAPK‐signaling axis. Journal of Cellular Physiology.

Zeng, C., Guo, J., Wu, J., Che, T., Huang, X., Liu, H., & Lin, Z. (2023). HRD1 promotes non-small cell lung carcinoma metastasis by blocking autophagy-mediated MIEN1 degradation. Journal of Biological Chemistry, 299(6).

Tripathi, A. K., Desai, P. P., & Vishawanatha, J. K. (2023). First Report of the Peptide Inhibitors of Cancer Cell Migration From MIEN1 Protein Sequence.

Xu, J., Qu, Q., Liu, B., & Shen, L. (2022). The circular RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1) axis promotes the progression of polycystic ovary syndrome. Bioengineered, 13(3), 5999-6011.

Liu, Y., Wang, X., Li, H., Guan, E., & Luo, K. (2021). Propofol ameliorates the proliferation and epithelial-mesenchymal transition of hepatoma carcinoma cells via non-coding RNA activated by DNA damage (NORAD)/microRNA (miR)-556-3p/migration and invasion enhancer 1 (MIEN1) axis. Journal of Environmental Pathology, Toxicology and Oncology, 40(4).

Liang, F., Zhang, H., Qiu, Y., Xu, Q., Jian, K., Jiang, L., ... & Lu, X. (2020). MiR-124-5p inhibits the progression of gastric cancer by targeting MIEN1. Technology in Cancer Research & Treatment, 19, 1533033820979199.

Yu, X., Xiao, W., Song, H., Jin, Y., Xu, J., & Liu, X. (2020). CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression. Gene, 748, 144678.

Cámara-Quílez, M., Barreiro-Alonso, A., Vizoso-Vázquez, Á., Rodríguez-Belmonte, E., Quindós-Varela, M., Lamas-Maceiras, M., & Cerdán, M. E. (2020). The HMGB1-2 ovarian cancer interactome. The role of HMGB proteins and their interacting partners MIEN1 and NOP53 in ovary cancer and drug-response. Cancers, 12(9), 2435.

Kushwaha, P. P., Gupta, S., Singh, A. K., & Kumar, S. (2019). Emerging role of migration and invasion enhancer 1 (MIEN1) in cancer progression and metastasis. Frontiers in oncology, 9, 868.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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