Mouse Anti-MINPP1 Recombinant Antibody (CBFYM-2230) (CBMAB-M2413-FY)

Name: Mouse Anti-MINPP1 Recombinant Antibody (CBFYM-2230)
SKU: CBMAB-M2413-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2230

Application

Immunogen

Full length human recombinant protein of human MINPP1(NP_004888) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MULTIPLE INOSITOL-POLYPHOSPHATE PHOSPHATASE 1

Introduction

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase in the Rapoport-Luebering shunt of the glycolytic pathway.

Entrez Gene ID

9562

UniProt ID

Q9UNW1

Alternative Names

Multiple Inositol-Polyphosphate Phosphatase 1; Multiple Inositol Polyphosphate Histidine Phosphatase, 1; Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase; 2,3-Bisphosphoglycerate 3-Phosphatase; Ins(1,3,4,5)P(4) 3-Phosphatase; 2,3-BPG Phosphatase; EC 3.1.3.62

Function

Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).

Biological Process

Bone mineralization Source: UniProtKB
Inositol phosphate metabolic process Source: Reactome
Ossification Source: UniProtKB
Polyphosphate metabolic process Source: ProtInc

Cellular Location

Endoplasmic reticulum lumen

Involvement in disease

Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.

Ullah, A., Shah, A. A., Alluqmani, M., Haider, N., Aman, H., Alfadhli, F., ... & Basit, S. (2022). Clinical and genetic characterization of patients segregating variants in KPTN, MINPP1, NGLY1, AP4B1, and SON underlying neurodevelopmental disorders: Genetic and phenotypic expansion. International Journal of Developmental Neuroscience, 82(8), 788-804.

Nguyen Trung, M., Kieninger, S., Fandi, Z., Qiu, D., Liu, G., Mehendale, N. K., ... & Fiedler, D. (2022). Stable isotopomers of myo-inositol uncover a complex MINPP1-dependent inositol phosphate network. ACS Central Science, 8(12), 1683-1694.

Zubair, M., Hamzah, R., Griffin, R., & Ali, N. (2022). Identification and functional characterization of multiple inositol polyphosphate phosphatase1 (Minpp1) isoform-2 in exosomes with potential to modulate tumor microenvironment. Plos one, 17(3), e0264451.

Appelhof, B., Wagner, M., Hoefele, J., Heinze, A., Roser, T., Koch-Hogrebe, M., ... & Jamra, R. A. (2021). Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1. European Journal of Human Genetics, 29(3), 411-421.

Chen, W., Jiang, J., Gong, L., Shu, Z., Xiang, D., Zhang, X., ... & Diao, H. (2021). Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis. Journal of Experimental & Clinical Cancer Research, 40, 1-18.

Ucuncu, E., Rajamani, K., Wilson, M. S., Medina-Cano, D., Altin, N., David, P., ... & Cantagrel, V. (2020). MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nature communications, 11(1), 6087.

Ucuncu, E., Rajamani, K., Wilson, M. S., Medina-Cano, D., Altin, N., David, P., ... & Cantagrel, V. (2020). MINPP1 prevents intracellular accumulation of the cation chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. bioRxiv, 2020-05.

Shi, L., Liu, L., Lv, X., Ma, Z., Yang, Y., Li, Y., ... & Han, B. (2019). Polymorphisms and genetic effects of PRLR, MOGAT1, MINPP1 and CHUK genes on milk fatty acid traits in Chinese Holstein. BMC genetics, 20(1), 1-8.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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