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Rabbit Anti-MIOS Recombinant Antibody (CBFYM-2231) (CBMAB-M2414-FY)

This product is rabbit antibody that recognizes MIOS. The antibody CBFYM-2231 can be used for immunoassay techniques such as: WB, IP.
See all MIOS antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYM-2231
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Meiosis Regulator For Oocyte Development
Introduction
MIOS is a Protein Coding gene. Among its related pathways are PI3K/Akt Signaling and mTOR signaling pathway.
Entrez Gene ID
Human54468
Mouse252875
Rat362324
UniProt ID
HumanQ9NXC5
MouseQ8VE19
RatD3Z9C0
Alternative Names
Meiosis Regulator For Oocyte Development; Missing Oocyte Meiosis Regulator Homolog; WD Repeat-Containing Protein Mio; Missing Oocyte, Meiosis Regulator, Homolog (Drosophila); Missing Oocyte, Meiosis Regulator, Homolog; GATOR Complex Protein MIOS
Function
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).

It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Biological Process
Cellular response to amino acid starvation Source: UniProtKB
Negative regulation of TORC1 signaling Source: ComplexPortal
Positive regulation of TORC1 signaling Source: GO_Central
Positive regulation of TOR signaling Source: SGD
Protein-containing complex localization Source: UniProtKB
Cellular Location
Lysosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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