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Mouse Anti-MKX Recombinant Antibody (CBFYM-2269) (CBMAB-M2454-FY)

This product is mouse antibody that recognizes MKX. The antibody CBFYM-2269 can be used for immunoassay techniques such as: WB, IHC.
See all MKX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2269
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human MKX(NP_775847) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MOHAWK HOMEOBOX
Introduction
The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
283078
UniProt ID
Q8IYA7
Alternative Names
Mohawk Homeobox; Iroquois Homeobox Protein-Like 1; C10orf48; IRXL1; Iroquois Family Related Homeodomain Protein; Chromosome 10 Open Reading Frame 48; Homeobox Protein Mohawk; IFRX
Function
May act as a morphogenetic regulator of cell adhesion.
Biological Process
Cell development Source: GO_Central
Muscle organ development Source: HGNC-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Yagasaki, L., Chiba, T., Kurimoto, R., Nakajima, M., Iwata, T., & Asahara, H. (2024). The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum. Regenerative Therapy, 25, 186-193.

Abdul Majeed, S., Dunzendorfer, H., Weiner, J., Heiker, J. T., Kiess, W., Körner, A., & Landgraf, K. (2023). COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children. International Journal of Molecular Sciences, 24(4), 3085.

Fujisawa, Y., Ming, L., Yamada, D., Takao, T., & Takarada, T. (2022). Establishment of a human pluripotent stem cell-derived MKX-td Tomato reporter system. Stem Cell Research & Therapy, 13(1), 1-8.

Adachi, Y., Higuchi, A., Wakai, E., Shiromizu, T., Koiwa, J., & Nishimura, Y. (2022). Involvement of homeobox transcription factor Mohawk in palatogenesis. Congenital Anomalies, 62(1), 27-37.

Takada, K., Chiba, T., Miyazaki, T., Yagasaki, L., Nakamichi, R., Iwata, T., ... & Asahara, H. (2022). Single cell RNA sequencing reveals critical functions of Mkx in periodontal ligament homeostasis. Frontiers in Cell and Developmental Biology, 10, 795441.

Chen, G., Fan, D., Zhang, W., Wang, S., Gu, J., Gao, Y., ... & Hao, Q. (2021). Mkx mediates tenogenic differentiation but incompletely inhibits the proliferation of hypoxic MSCs. Stem Cell Research & Therapy, 12(1), 1-15.

Miyazaki, T., Kurimoto, R., Chiba, T., Matsushima, T., Nakamichi, R., Tsutsumi, H., ... & Asahara, H. (2021). Mkx regulates the orthodontic tooth movement via osteoclast induction. Journal of Bone and Mineral Metabolism, 39(5), 780-786.

Yang, F., Zhang, A., & Richardson, D. W. (2019). Regulation of the tenogenic gene expression in equine tenocyte-derived induced pluripotent stem cells by mechanical loading and Mohawk. Stem cell research, 39, 101489.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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