Mouse Anti-MLC1 Recombinant Antibody (CBFYM-0655) (CBMAB-M0791-FY)

Name: Mouse Anti-MLC1 Recombinant Antibody (CBFYM-0655)
SKU: CBMAB-M0791-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0655

Application

ELISA

Specificity

Cattle

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 1

Introduction

A reduction in milk lactose content could be beneficial for nutritional but also agricultural and industrial purposes.

Entrez Gene ID

101410076

UniProt ID

Q08E21

Alternative Names

MLC

Function

Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.

Biological Process

Caveolin-mediated endocytosis Source: UniProtKB
Cellular response to cholesterol Source: UniProtKB
Ion transport Source: UniProtKB-KW
Positive regulation of intracellular transport Source: UniProtKB
Protein transport Source: Ensembl
Regulation of response to osmotic stress Source: UniProtKB
Vesicle-mediated transport Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Plasma membrane
Cell membrane
Other locations
Membrane
perinuclear region

Involvement in disease

Leukoencephalopathy, megalencephalic, with subcortical cysts, 1 (MLC1):
A syndrome of cerebral leukoencephalopathy and megalencephaly characterized by ataxia, spasticity, seizures, delay in motor development and mild mental retardation. The brain appears swollen on magnetic resonance imaging, with diffuse white-matter abnormalities and the invariable presence of subcortical cysts in frontal and temporal lobes.

Brignone, M. S., Lanciotti, A., Michelucci, A., Mallozzi, C., Camerini, S., Catacuzzeno, L., ... & Ambrosini, E. (2022). The CaMKII/MLC1 Axis Confers Ca2+-Dependence to Volume-Regulated Anion Channels (VRAC) in Astrocytes. Cells, 11(17), 2656.

Brignone, M. S., Lanciotti, A., Michelucci, A., Mallozzi, C., Camerini, S., Catacuzzeno, L., ... & Ambrosini, E. (2022). MLC1: A New Calcium-regulated Protein Conferring Calcium Dependence to Volume-regulated Anion Channels (VRAC) in Astrocytes.

Hwang, J., Vu, H. M., Kim, M. S., & Lim, H. H. (2019). Plasma membrane localization of MLC1 regulates cellular morphology and motility. Molecular brain, 12(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MLC1 Recombinant Antibody (CBFYM-2282) (CAT#: CBMAB-M2467-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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