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Mouse Anti-MLN Recombinant Antibody (CBFYM-2310) (CBMAB-M2495-FY)

This product is mouse antibody that recognizes MLN. The antibody CBFYM-2310 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all MLN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2310
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
motilin
Introduction
This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide. Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene.
Entrez Gene ID
4295
UniProt ID
P12872
Alternative Names
Motilin; Prepromotilin; Promotilin
Function
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
Cellular Location
Secreted

Cho, M. S., Park, J. W., Kim, J., & Ko, S. J. (2023). The influence of herbal medicine on serum motilin and its effect on human and animal model: a systematic review. Frontiers in Pharmacology, 14.

Kaiya, H. (2021). Ghrelin-motilin family. In Handbook of Hormones (pp. 317-319). Academic Press.

Miedzybrodzka, E. L., Foreman, R. E., Lu, V. B., George, A. L., Smith, C. A., Larraufie, P., ... & Gribble, F. M. (2021). Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids. Molecular metabolism, 54, 101356.

Wang, Y. Y., Lu, R. Y., Shi, J., Zhao, S., Jiang, X., & Gu, X. (2021). CircORC2 is involved in the pathogenesis of slow transit constipation via modulating the signalling of miR‐19a and neurotensin/motilin. Journal of Cellular and Molecular Medicine, 25(8), 3754-3764.

Kitazawa, T., & Kaiya, H. (2021). Motilin comparative study: structure, distribution, receptors, and gastrointestinal motility. Frontiers in Endocrinology, 12, 700884.

Rajkumar, R. P. (2021). Gut hormones as potential therapeutic targets or biomarkers of response in depression: The case of Motilin. Life, 11(9), 892.

Zhang, S., Teraoka, H., Kaiya, H., & Kitazawa, T. (2021). Motilin-and ghrelin-induced contractions in isolated gastrointestinal strips from three species of frogs. General and Comparative Endocrinology, 300, 113649.

Kitazawa, T., Harada, R., Sakata, I., Sakai, T., & Kaiya, H. (2019). A verification study of gastrointestinal motility-stimulating action of guinea-pig motilin using isolated gastrointestinal strips from rabbits and guinea-pigs. General and Comparative Endocrinology, 274, 106-112.

Kitazawa, T., & Kaiya, H. (2019). Regulation of gastrointestinal motility by motilin and ghrelin in vertebrates. Frontiers in endocrinology, 10, 278.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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