Sign in or Register   Sign in or Register
  |  

Mouse Anti-MME Recombinant Antibody (SS2/36) (CBMAB-N0088-WJ)

This product is a Mouse antibody that recognizes MME. The antibody SS2/36 can be used for immunoassay techniques such as: WB, FC, IHC, CyTOF.
See all MME antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
SS2/36
Antibody Isotype
IgG1
Application
WB, FC, IHC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.0 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Membrane Metalloendopeptidase
Introduction
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
Entrez Gene ID
UniProt ID
Alternative Names
Membrane Metalloendopeptidase; Common Acute Lymphocytic Leukemia Antigen; Neutral Endopeptidase 24.11; Skin Fibroblast Elastase; Neutral Endopeptidase; Atriopeptidase; Enkephalinase; EC 3.4.24.11; Neprilysin; CALLA; NEP; SFE;
Function
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535).

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991).

Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675).

Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193).

Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Biological Process
Aging Source: ARUK-UCL
Amyloid-beta clearance Source: ARUK-UCL
Amyloid-beta clearance by cellular catabolic process Source: ARUK-UCL
Amyloid-beta metabolic process Source: UniProtKB
Cellular response to cytokine stimulus Source: UniProtKB
Cellular response to UV-A Source: UniProtKB
Cellular response to UV-B Source: UniProtKB
Creatinine metabolic process Source: UniProtKB
Kidney development Source: UniProtKB
Learning or memory Source: ARUK-UCL
Lung development Source: Ensembl
Neuropeptide processing Source: ARUK-UCL
Peptide metabolic process Source: UniProtKB
Placenta development Source: Ensembl
Positive regulation of long-term synaptic potentiation Source: Ensembl
Positive regulation of neurogenesis Source: ARUK-UCL
Protein processing Source: GO_Central
Proteolysis Source: UniProtKB
Replicative senescence Source: UniProtKB
Sensory perception of pain Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Charcot-Marie-Tooth disease 2T (CMT2T):
An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
Spinocerebellar ataxia 43 (SCA43):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA43 is a slowly progressive, autosomal dominant form.
Topology
Cytoplasmic: 2-28
Helical: 29-51
Extracellular: 52-750
PTM
Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.

Ding, J., Li, C., Shu, K., Chen, W., Cai, C., Zhang, X., & Zhang, W. (2023). Membrane metalloendopeptidase (MME) is positively correlated with systemic lupus erythematosus and may inhibit the occurrence of breast cancer. Plos one, 18(8), e0289960.

Mina, M., Conway, R., Haga, R., Obregon, C., Patel, P., Comstock, M., ... & Zaki, M. (2022). eP043: Membrane Metalloendopeptidase (MME) positively regulates Phosphoinositide 3-Kinase (PI3K) signaling in triple negative breast cancer. Genetics in Medicine, 24(3), S29.

Jamiri, Z., Khosravi, R., Heidari, M. M., Kiani, E., & Gharechahi, J. (2022). A nonsense mutation in MME gene associates with autosomal recessive late‐onset Charcot–Marie–Tooth disease. Molecular Genetics & Genomic Medicine, 10(5), e1913.

Weiß, E., Berger, H. M., Brandl, W. T., Strutz, J., Hirschmugl, B., Simovic, V., ... & Hiden, U. (2020). Maternal overweight downregulates MME (neprilysin) in feto-placental endothelial cells and in cord blood. International Journal of Molecular Sciences, 21(3), 834.

Cheng, C. Y., Zhou, Z., Stone, M., Lu, B., Flesken-Nikitin, A., Nanus, D. M., & Nikitin, A. Y. (2020). Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells. Oncogenesis, 9(3), 38.

Zhang, S., Xiao, T., Yu, Y., Qiao, Y., Xu, Z., Geng, J., ... & Suo, G. (2019). The extracellular matrix enriched with membrane metalloendopeptidase and insulin‐degrading enzyme suppresses the deposition of amyloid‐beta peptide in Alzheimer's disease cell models. Journal of Tissue Engineering and Regenerative Medicine, 13(10), 1759-1769.

Li, M., Wang, L., Zhan, Y., Zeng, T., Zhang, X., Guan, X. Y., & Li, Y. (2019). Membrane metalloendopeptidase (MME) suppresses metastasis of esophageal squamous cell carcinoma (ESCC) by inhibiting FAK-RhoA signaling axis. The American Journal of Pathology, 189(7), 1462-1472.

Hong, D., Fang, P., Yao, S., Chen, J., Zhang, X., Chen, S., ... & Zhang, J. (2019). Variants in MME are associated with autosomal‐recessive distal hereditary motor neuropathy. Annals of Clinical and Translational Neurology, 6(9), 1728-1738.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-MME Recombinant Antibody (SS2/36)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare