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Mouse Anti-MMP17 (AA 42-534) Recombinant Antibody (CBFYM-2376) (CBMAB-M2563-FY)

This product is mouse antibody that recognizes MMP17. The antibody CBFYM-2376 can be used for immunoassay techniques such as: Neut.
See all MMP17 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2376
Antibody Isotype
IgG2a
Application
Neut

Basic Information

Immunogen
Recombinant human MMP-17, Pro42-Ala534
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 42-534

Target

Full Name
MATRIX METALLOPEPTIDASE 17
Introduction
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers.
Entrez Gene ID
4326
UniProt ID
Q9ULZ9
Alternative Names
Matrix Metallopeptidase 17; Matrix Metalloproteinase 17 (Membrane-Inserted); Matrix Metallopeptidase 17 (Membrane-Inserted); Membrane-Type Matrix Metalloproteinase 4; Membrane-Type-4 Matrix Metalloproteinase; MT-MMP 4; MT4-MMP
Function
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
Biological Process
Collagen catabolic process Source: GO_Central
Drinking behavior Source: Ensembl
Extracellular matrix organization Source: GO_Central
Kidney development Source: Ensembl
Proteolysis Source: ParkinsonsUK-UCL
Cellular Location
Isoform Long:
Plasma membrane
Cell membrane
Extracellular region or secreted
extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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