Sign in or Register   Sign in or Register
  |  

Mouse Anti-MMP21 Recombinant Antibody (2F10) (CBMAB-A5529-LY)

The product is antibody recognizes MMP21. The antibody 2F10 immunoassay techniques such as: WB, ELISA.
See all MMP21 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MMP21 (NP_671724.1, 374 a.a. ~ 481 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
matrix metallopeptidase 21
Introduction
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq]
Entrez Gene ID
118856
UniProt ID
Q8N119
Function
Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028).

Cleaves alpha-1-antitrypsin (PubMed:12617721).
Biological Process
Collagen catabolic process Source: GO_Central
Coronary vasculature development Source: Ensembl
Determination of heart left/right asymmetry Source: UniProtKB
Determination of left/right symmetry Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Hematopoietic progenitor cell differentiation Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Heterotaxy, visceral, 7, autosomal (HTX7):
A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations. HTX7 inheritance is autosomal recessive.
PTM
The precursor is cleaved by a furin endopeptidase.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MMP21 Recombinant Antibody (2F10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare