Mouse Anti-MMP21 Recombinant Antibody (2F10) (CBMAB-A5529-LY)

Name: Mouse Anti-MMP21 Recombinant Antibody (2F10)
SKU: CBMAB-A5529-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F10

Application

WB, ELISA

Immunogen

MMP21 (NP_671724.1, 374 a.a. ~ 481 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

matrix metallopeptidase 21

Introduction

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq]

Entrez Gene ID

118856

UniProt ID

Q8N119

Function

Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028).

Cleaves alpha-1-antitrypsin (PubMed:12617721).

Biological Process

Collagen catabolic process Source: GO_Central
Coronary vasculature development Source: Ensembl
Determination of heart left/right asymmetry Source: UniProtKB
Determination of left/right symmetry Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Hematopoietic progenitor cell differentiation Source: Ensembl

Cellular Location

Secreted

Involvement in disease

Heterotaxy, visceral, 7, autosomal (HTX7):
A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations. HTX7 inheritance is autosomal recessive.

PTM

The precursor is cleaved by a furin endopeptidase.

Zhou, J., Liu, L., Hu, X., Feng, R., Zhao, N., Zhang, L., ... & Jin, J. (2023). Matrix metalloproteinase‐21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC. Cancer Science, 114(2), 423-435.

Xiang, Y., Liu, L., Wang, Y., Li, B., Peng, J., & Feng, D. (2020). ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21. Cancer Cell International, 20, 1-11.

Rusek, M., Michalska-Jakubus, M., Kowal, M., Bełtowski, J., & Krasowska, D. (2019). A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients. Scientific reports, 9(1), 14264.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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