Mouse Anti-MMP26 (AA 152-261) Recombinant Antibody (CBFYM-2396) (CBMAB-M2583-FY)

Name: Mouse Anti-MMP26 (AA 152-261) Recombinant Antibody (CBFYM-2396)
SKU: CBMAB-M2583-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2396

Antibody Isotype

IgG1, k

Application

ELISA, WB

Basic Information

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: SFWQWAHEDG WPFDGPGGIL GHAFLPNSGN PGVVHFDKNE HWSASDTGYN LFLVATHEIG HSLGLQHSGN QSSIMYPTYW YHDPRTFQLS ADDIQRIQHL YGEKCSSDIP

Specificity

Human

Antibody Isotype

IgG1, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 152-261

Target

Full Name

matrix metallopeptidase 26

Introduction

Proteins of the matrix metalloproteinase family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers.

Entrez Gene ID

56547

UniProt ID

Q9NRE1

Alternative Names

Matrix Metallopeptidase 26; Matrilysin 2; Endometase; MMP-26; Matrix Metalloproteinase 26; Matrix Metalloproteinase-26; Matrilysin-2; EC 3.4.24.-

Function

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Biological Process

Collagen catabolic process Source: GO_Central
Extracellular matrix organization Source: GO_Central
Negative regulation of inflammatory response Source: CACAO
Proteolysis Source: UniProtKB

Cellular Location

Extracellular matrix

More Infomation

References

da Silva, R. L., de Lima, I. T., Luís Almeida Paes, F., Souza da Silva, S. M., Almeida Diniz Gurgel, A. P., Santos, F., & da Costa Silva Neto, J. (2021). MATRIX METALLOPROTEINASE 26 (MMP-26) OVEREXPRESSION IN PROSTATIC ADENOCARCINOMA. medRxiv, 2021-05.

Piskór, B. M., Przylipiak, A., Dąbrowska, E., Sidorkiewicz, I., Niczyporuk, M., Szmitkowski, M., & Ławicki, S. (2021). Plasma concentrations of matrilysins MMP-7 and MMP-26 as diagnostic biomarkers in breast cancer. Journal of Clinical Medicine, 10(7), 1436.

Piskór, B. M., Przylipiak, A., Dąbrowska, E., Sidorkiewicz, I., Niczyporuk, M., Szmitkowski, M., & Ławicki, S. (2020). Plasma Matrilysins MMP-7 and MMP-26 Concentrations as Diagnostic Biomarkers for Breast Cancer Patients.

Zhang, G., Zhang, J., Li, X., Meng, X., & Fang, X. (2019). Identification of the endoplasmic reticulum localization sequence and N-glycosylation of matrix metalloproteinase 26. RSC advances, 9(40), 23053-23060.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MMP26 Recombinant Antibody (6C6)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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