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Mouse Anti-MND1 Recombinant Antibody (CBFYM-2436) (CBMAB-M2623-FY)

This product is mouse antibody that recognizes MND1. The antibody CBFYM-2436 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MND1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-2436
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MEIOTIC NUCLEAR DIVISIONS 1
Introduction
The product of the MND1 gene associates with HOP2 to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 and DMC1 . Both the MND1 and HOP2 genes are indispensable for meiotic recombination.
Entrez Gene ID
Human84057
Mouse76915
Rat295160
UniProt ID
HumanQ9BWT6
MouseQ8K396
RatF1LWN6
Alternative Names
Meiotic Nuclear Divisions 1; GAJ; Meiotic Nuclear Divisions 1 Homolog (S. Cerevisiae); Meiotic Nuclear Division Protein 1 Homolog; Meiotic Nuclear Divisions 1 Homolog; Homolog Of Yeast MND1
Function
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity).

Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Biological Process
Reciprocal meiotic recombination Source: GO_Central
Cellular Location
Nucleus

Tsubouchi, H. (2023). The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination. Biomolecules, 13(4), 662.

Zhao, J., Ji, Z., Meng, G., Luo, J., Zhang, Y., Ou, N., ... & Li, P. (2023). Identification of a missense variant of MND1 in meiotic arrest and non-obstructive azoospermia. Journal of Human Genetics, 1-7.

Zelceski, A., Francica, P., Lingg, L., Mutlu, M., Stok, C., Liptay, M., ... & Lord, C. J. (2023). MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells. Cell reports, 42(5).

Tan, K., Wang, K., Zhao, A., Liu, Z., Song, W., Cheng, Q., ... & Yang, Z. (2022). Meiotic nuclear divisions 1 promotes proliferation and metastasis in hepatocellular carcinoma and is a potential diagnostic and therapeutic target gene. Medical Oncology, 40(1), 14.

Zhang, Q., Shi, R., Bai, Y., Meng, L., Hu, J., Zhu, H., ... & Yin, R. (2021). Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma. Cancer Communications, 41(6), 492-510.

Tran, T. N., Martinez, J., & Schimenti, J. C. (2019). A predicted deleterious allele of the essential meiosis gene MND1, present in~ 3% of East Asians, does not disrupt reproduction in mice. Molecular human reproduction, 25(10), 668-673.

Crickard, J. B., Kwon, Y., Sung, P., & Greene, E. C. (2019). Dynamic interactions of the homologous pairing 2 (Hop2)–meiotic nuclear divisions 1 (Mnd1) protein complex with meiotic presynaptic filaments in budding yeast. Journal of Biological Chemistry, 294(2), 490-501.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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