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Mouse Anti-MOB1A (AA 1-216) Recombinant Antibody (CBFYM-2448) (CBMAB-M2635-FY)

This product is mouse antibody that recognizes MOB1A. The antibody CBFYM-2448 can be used for immunoassay techniques such as: ELISA, WB, FC.
See all MOB1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2448
Antibody Isotype
IgG2b
Application
ELISA, WB, FC

Basic Information

Immunogen
Recombinant fragment of human MOB1A (AA: 1-216) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-216

Target

Full Name
MOB KINASE ACTIVATOR 1A
Introduction
The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
MOB Kinase Activator 1A; Mps One Binder Kinase Activator-Like 1B; Mob1 Homolog 1B; Mob1 Alpha; MOBKL1B; C2orf6; MOBK1B; Mob4B; MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast)
Function
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
Biological Process
Hippo signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Signal transduction Source: GO_Central
Cellular Location
Cytosol
Extracellular region or secreted
extracellular exosome
Nucleus
nucleolus
nucleoplasm
Other locations
cytoplasm
PTM
Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.

Lei, J., Xu, J. Y., Hu, M., Wu, S. G., & Zhou, J. (2023). MOB kinase activator 1A acts as an oncogene by targeting PI3K/AKT/mTOR in ovarian cancer. Discover Oncology, 14(1), 100.

Eisazaei, S., Nakhaee-Moghadam, M., & Kordi Tamandani, D. M. (2022). Analysis of Expression Profiles of GLI3A, LATS2 and MOB1A genes in Patients with Congenital hypothyroidism. Journal of Epigenetics, 3(1), 21-26.

Yang, P., Zhang, D., Wang, T., Ji, J., Jin, C., Peng, C., ... & Sun, Y. (2022). CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway. Cell Death & Disease, 13(9), 796.

Cui, X., Su, H., Yang, J., Wu, X., Huo, K., Jing, X., & Zhang, S. (2022). Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling. Journal of Ovarian Research, 15(1), 23.

Meng, L., Chang, S., Sang, Y., Ding, P., Wang, L., Nan, X., ... & Sang, M. (2022). Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression. Breast Cancer Research, 24, 1-13.

Zhou, P. M., Liang, Y., Mei, J., Liao, H. Z., Wang, P., Hu, K., ... & Ye, D. (2021). The Arabidopsis AGC kinases NDR2/4/5 interact with MOB1A/1B and play important roles in pollen development and germination. The Plant Journal, 105(4), 1035-1052.

Yang, B., Li, Y., Zhang, R., Liu, L., Miao, H., Li, Y., ... & Shi, H. (2020). MOB1A regulates glucose deprivation-induced autophagy via IL6-STAT3 pathway in gallbladder carcinoma. American journal of cancer research, 10(11), 3896.

Lee, P. C., Beyrakhova, K., Xu, C., Boniecki, M. T., Lee, M. H., Onu, C. J., ... & Cygler, M. (2020). The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Proceedings of the National Academy of Sciences, 117(25), 14433-14443.

Bae, J. S., Kim, S. M., Jeon, Y., Sim, J., Jang, J. Y., Son, J., ... & Lee, H. (2019). Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages. Experimental & molecular medicine, 51(11), 1-12.

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For research use only. Not intended for any clinical use.

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