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Mouse Anti-MOCOS (AA 1-888) Recombinant Antibody (CBFYM-2460) (CBMAB-M2647-FY)

This product is mouse antibody that recognizes MOCOS. The antibody CBFYM-2460 can be used for immunoassay techniques such as: ELISA, WB.
See all MOCOS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2460
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAGAAAESGR ELWTFAGSRD PSAPRLAYGY GPGSLRELRA REFSRLAGTV YLDHAGATLF SQSQLESFTS DLMENTYGNP HSQNISSKLT HDTVEQVRYR ILAHFHTTAE DYTVIFTAGS TAALKLVAEA FPWVSQGPES S
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-888

Target

Full Name
molybdenum cofactor sulfurase
Introduction
This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase and aldehyde oxidase enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine.
Entrez Gene ID
55034
UniProt ID
Q96EN8
Alternative Names
Molybdenum Cofactor Sulfurase; HMCS; MCS; MOS; Molybdenum Cofactor Sulfurtransferase; MoCo Sulfurase; EC 2.8.1.9
Function
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.
Biological Process
Molybdopterin cofactor biosynthetic process Source: Reactome
Molybdopterin cofactor metabolic process Source: UniProtKB
Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-UniRule
Cellular Location
Cytosol
Involvement in disease
Xanthinuria 2 (XAN2):
A disorder characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. In addition, XAN2 patients cannot metabolize allopurinol into oxypurinol due to dual deficiency of xanthine dehydrogenase and aldehyde oxidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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