Rabbit Anti-MOK Recombinant Antibody (D1A12) (CBMAB-CP2201-LY)

Name: Rabbit Anti-MOK Recombinant Antibody (D1A12)
SKU: CBMAB-CP2201-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D1A12

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RAGE 1 protein.

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MOK Protein Kinase

Introduction

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Entrez Gene ID

Human	5891
Monkey	106999576

UniProt ID

Human	Q9UQ07
Monkey	F7DNC0

Alternative Names

MOK Protein Kinase; Renal Tumor Antigen 1; RAGE-1; RAGE1; RAGE; MAPK/MAK/MRK Overlapping Kinase;

Function

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Biological Process

Intracellular signal transduction Source: GO_Central
Protein phosphorylation Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Cytoplas
Nucleus
Other locations
cilium

PTM

Autophosphorylated.

Pérez-Cabello, J. A., Silvera-Carrasco, L., Franco, J. M., Capilla-González, V., Armaos, A., Gómez-Lima, M., ... & Roodveldt, C. (2023). MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Proceedings of the National Academy of Sciences, 120(28), e2302143120.

Hwang, J. H., Ma, J. N., Park, J. H., Jung, H. W., & Park, Y. K. (2019). Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages. International journal of molecular medicine, 43(1), 26-36.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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