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Rabbit Anti-MPC2 Recombinant Antibody (CBFYM-2483) (CBMAB-M2670-FY)

This product is rabbit antibody that recognizes MPC2. The antibody CBFYM-2483 can be used for immunoassay techniques such as: IP, WB.
See all MPC2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Mouse, Rat
Clone
CBFYM-2483
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Asn33 of human MPC2
Specificity
Human, Monkey, Mouse, Rat
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 0.15 M NaCl, 0.01% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitochondrial Pyruvate Carrier 2
Introduction
MPC2 is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology annotations related to this gene include pyruvate transmembrane transporter activity.
Entrez Gene ID
Human25874
Mouse70456
Rat100359982
Monkey698807
UniProt ID
HumanO95563
MouseQ9D023
RatP38718
MonkeyG7MF91
Alternative Names
Mitochondrial Pyruvate Carrier 2; Brain Protein 44; BRP44; SLC54A2
Function
Mediates the uptake of pyruvate into mitochondria.
Biological Process
Nitochondrial acetyl-CoA biosynthetic process from pyruvate Source: Ensembl
Nitochondrial pyruvate transmembrane transport Source: GO_Central
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Cellular Location
Mitochondrion inner membrane

Tavoulari, S., Sichrovsky, M., & Kunji, E. R. (2023). Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition. Acta Physiologica, 238(4), e14016.

Pujol, C., Lebigot, E., Gaignard, P., Galai, S., Kraoua, I., Bault, J. P., ... & Slama, A. (2023). MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy. Brain, 146(3), 858-864.

Jiang, H., Alahmad, A., Fu, S., Fu, X., Liu, Z., Han, X., ... & Fang, F. (2022). Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. Journal of Inherited Metabolic Disease, 45(2), 264-277.

Fernandez-Caggiano, M., & Eaton, P. (2021). Heart failure—Emerging roles for the mitochondrial pyruvate carrier. Cell Death & Differentiation, 28(4), 1149-1158.

Ruiz-Iglesias, A., & Mañes, S. (2021). The importance of mitochondrial pyruvate carrier in cancer cell metabolism and tumorigenesis. Cancers, 13(7), 1488.

Zangari, J., Petrelli, F., Maillot, B., & Martinou, J. C. (2020). The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier. Biomolecules, 10(7), 1068.

Buchanan, J. L., & Taylor, E. B. (2020). Mitochondrial pyruvate carrier function in health and disease across the lifespan. Biomolecules, 10(8), 1162.

Feng, J., Ma, Y., Chen, Z., Hu, J., Yang, Q., & Ding, G. (2019). Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes. Life sciences, 237, 116941.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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