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  • Mouse Anti-MPDZ (AA 65-247) Recombinant Antibody (CBFYM-2484)

Mouse Anti-MPDZ (AA 65-247) Recombinant Antibody (CBFYM-2484) (CBMAB-M2671-FY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBFYM-2484
Application
WB
Immunogen
Rat MUPP1 aa. 65-247
Specificity
Rat, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 65-247
More Infomation

Target

Full Name
MULTIPLE PDZ DOMAIN CRUMBS CELL POLARITY COMPLEX COMPONENT
Introduction
Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.
Entrez Gene ID
Mouse17475
Rat29365
UniProt ID
MouseQ8VBX6
RatO55164
Alternative Names
MUPP1; AI225843; B930003D11Rik
Function
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654).

Promotes clustering of HT2RC at the cell surface (By similarity).
Biological Process
Microtubule organizing center organization Source: GO_Central
Regulation of microtubule cytoskeleton organization Source: GO_Central
Tight junction assembly Source: GO_Central
Cellular Location
Plasma membrane
Cell membrane
Apical cell membrane
Other locations
postsynaptic density
dendrite
tight junction
synapse
synaptosome
Note: Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.
Involvement in disease
Hydrocephalus, congenital, 2, with or without brain or eye anomalies (HYC2):
A form of congenital hydrocephalus, a disease characterized by onset in utero of enlarged ventricles due to accumulation of ventricular cerebrospinal fluid. HYC2 affected individuals have variable neurologic impairment. Some individuals have other brain abnormalities, including lissencephaly, thinning of the corpus callosum, and neuronal heterotopia. Most patients have delayed motor development and some have delayed intellectual development and/or seizures. Additional congenital features, including cardiac septal defects, iris coloboma, and non-specific dysmorphic features, may be observed. HYC2 inheritance is autosomal recessive.

Chen, Z., Ba, Y., Zhao, N., Dang, Q., Xu, H., Weng, S., ... & Liu, Z. (2024). MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer. Cellular Signalling, 114, 110967.

Gao, H., Ruge, F., Ye, L., Lane, J., Davies, E., Jiang, W. G., & Martin, T. A. (2023). Abstract P2-11-35: A tight junctional scaffold protein MUPP1/MPDZ and its docking proteins, angiomotins in breast cancer. Cancer Research, 83(5_Supplement), P2-11.

Chanez, B., Appay, R., Guille, A., Lagarde, A., Colin, C., Adelaide, J., ... & Tabouret, E. (2022). Genomic analysis of paired IDHwt glioblastomas reveals recurrent alterations of MPDZ at relapse after radiotherapy and chemotherapy. Journal of the Neurological Sciences, 436, 120207.

Jarysta, A., & Tarchini, B. (2021). Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells. Development, 148(14), dev199549.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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