Mouse Anti-MPZL2 Recombinant Antibody (G9P3-1) (CBMAB-E2205-FY)

Name: Mouse Anti-MPZL2 Recombinant Antibody (G9P3-1)
SKU: CBMAB-E2205-FY
Rating: 5 (1 reviews)

See all MPZL2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

G9P3-1

Application

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin, pH 7.2

Preservative

0.09% Sodium azide

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

myelin protein zero-like 2

Introduction

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.

Entrez Gene ID

Human	10205
Mouse	14012

UniProt ID

Human	O60487
Mouse	O70255

Alternative Names

Myelin Protein Zero Like 2; Epithelial V-Like Antigen 1; EVA1; EVA; Myelin Protein Zero-Like Protein 2

Function

Mediates homophilic cell-cell adhesion.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Cell-cell adhesion Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc

Cellular Location

Membrane

Involvement in disease

Deafness, autosomal recessive, 111 (DFNB111):
A form of non-syndromic, sensorineural deafness characterized by early-onset, moderate to severe hearing loss with no vestibular involvement. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Topology

Extracellular: 27-154
Helical: 155-175
Cytoplasmic: 176-215

Lo, E., Blair, J., Yamamoto, N., Diaz‐Miranda, M. A., Bedoukian, E., Gray, C., ... & Hartman, T. R. (2024). Recurrent missense variant identified in two unrelated families with MPZL2‐related hearing loss, expanding the variant spectrum associated with DFNB111. American Journal of Medical Genetics Part A.

Zhang, L., Yang, J. Y., Wang, Q. Q., Gao, X., Wang, G. J., Han, M. Y., ... & Yuan, Y. Y. (2024). MPZL2—a common autosomal recessive deafness gene related to moderate sensorineural hearing loss in the Chinese population. BMC Medical Genomics, 17(1), 32.

Li, W., Guo, L., Chen, B., Shu, Y., & Li, H. (2023). MPZL2 variant analysis with whole exome sequencing in a cohort of Chinese hearing loss patients. International Journal of Pediatric Otorhinolaryngology, 111635.

Wang, Z., Jiang, M., Wu, H., Li, Y., & Chen, Y. (2022). A novel MPZL2 c. 68delC variant is associated with progressive hearing loss in Chinese population and literature review. Laryngoscope Investigative Otolaryngology, 7(3), 870-876.

Eshibona, N., Giwa, A., Rossouw, S. C., Gamieldien, J., Christoffels, A., & Bendou, H. (2022). Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation. Leukemia & Lymphoma, 63(8), 1897-1906.

Amalou, G., Bonnet, C., Riahi, Z., Bouzidi, A., Elrharchi, S., Bousfiha, A., ... & Barakat, A. (2021). A homozygous MPZL2 deletion is associated with non syndromic hearing loss in a moroccan family. International Journal of Pediatric Otorhinolaryngology, 140, 110481.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-MPZL2 Recombinant Antibody (G9P3-1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MPZL2 (AA 27-136) Recombinant Antibody (CBFYM-2523) (CAT#: CBMAB-M2710-FY)

Mouse Anti-MPZL2 Recombinant Antibody (CBFYM-2522) (CAT#: CBMAB-M2709-FY)

Mouse Anti-MPZL2 Recombinant Antibody (CBFYM-0714) (CAT#: CBMAB-M0856-FY)

Mouse Anti-MPZL2 Recombinant Antibody (2E10) (CAT#: CBMAB-A5574-LY)

Mouse Anti-MPZL2 Recombinant Antibody (CBFYE-1557) (CAT#: CBMAB-E2206-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry