Mouse Anti-MRPL3 Recombinant Antibody (CBFYM-2559) (CBMAB-M2746-FY)

This product is mouse antibody that recognizes MRPL3. The antibody CBFYM-2559 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MRPL3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2559

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MITOCHONDRIAL RIBOSOMAL PROTEIN L3

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.

Entrez Gene ID

11222

UniProt ID

P09001

Alternative Names

Mitochondrial Ribosomal Protein L3; Mitochondrial Large Ribosomal Subunit Protein UL3m; MRP-L3; RPML3; L3mt; MRL3; 39S Ribosomal Protein L3, Mitochondrial; Mitochondrial 60S Ribosomal Protein L3; COXPD9

Biological Process

Mitochondrial translation Source: ComplexPortal
Translation Source: GO_Central

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 9 (COXPD9):
A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases.

References

Yin, J., Lin, C., Jiang, M., Tang, X., Xie, D., Chen, J., & Ke, R. (2021). CENPL, ISG20L2, LSM4, MRPL3 are four novel hub genes and may serve as diagnostic and prognostic markers in breast cancer. Scientific reports, 11(1), 15610.

Cahill, L. S., Cameron, J. M., Winterburn, J., Macos, P., Hoggarth, J., Dzamba, M., ... & Sled, J. G. (2020). Structural Variant in Mitochondrial-Associated Gene (MRPL3) induces adult-onset neurodegeneration with memory impairment in the mouse. Journal of Neuroscience, 40(23), 4576-4585.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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