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Mouse Anti-MRPL41 Recombinant Antibody (CBFYM-2562) (CBMAB-M2749-FY)

This product is mouse antibody that recognizes MRPL41. The antibody CBFYM-2562 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MRPL41 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2562
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MITOCHONDRIAL RIBOSOMAL PROTEIN L41
Introduction
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.
Entrez Gene ID
64975
UniProt ID
Q8IXM3
Alternative Names
Mitochondrial Ribosomal Protein L41; Bcl-2-Interacting Mitochondrial Ribosomal Protein L41; Mitochondrial Large Ribosomal Subunit Protein ML41; Cell Proliferation-Inducing Gene 3 Protein; 39S Ribosomal Protein L27 Homolog; MRP-L27 Homolog; MRP-L41; MRPL27
Function
Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503).

Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947).

Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell cycle Source: UniProtKB-KW
Mitochondrial translation Source: ComplexPortal
Translation Source: UniProtKB
Cellular Location
Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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