Mouse Anti-MRPS23 Recombinant Antibody (CBFYM-2578) (CBMAB-M2766-FY)

This product is mouse antibody that recognizes MRPS23. The antibody CBFYM-2578 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MRPS23 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2578

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MITOCHONDRIAL RIBOSOMAL PROTEIN S23

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p.

Entrez Gene ID

51649

UniProt ID

Q9Y3D9

Alternative Names

Mitochondrial Ribosomal Protein S23; Mitochondrial Small Ribosomal Subunit Protein MS23; MRP-S23; S23mt; 28S Ribosomal Protein S23, Mitochondrial; CGI-138; HSPC329

Biological Process

Mitochondrial translation Source: ComplexPortal

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 46 (COXPD46):
An autosomal recessive disorder characterized by childhood-onset mitochondrial respiratory chain complex deficiencies, particularly complexes I and IV, and hepatic disease.

References

Ittiwut, C., Ittiwut, R., Kuptanon, C., Matsuhashi, T., Shimura, M., Sugiyama, Y., ... & Shotelersuk, V. (2023). Genetic, metabolic and clinical delineation of an MRPS23-associated mitochondrial disorder. Scientific Reports, 13(1), 22005.

Oviya, R. P., Thangaretnam, K. P., Ramachandran, B., Ramanathan, P., Jayavelu, S., Gopal, G., & Rajkumar, T. (2022). Mitochondrial ribosomal small subunit (MRPS) MRPS23 protein–protein interaction reveals phosphorylation by CDK11-p58 affecting cell proliferation and knockdown of MRPS23 sensitizes breast cancer cells to CDK1 inhibitors. Molecular Biology Reports, 49(10), 9521-9534.

Oviya, R. P., Gopal, G., Shirley, S. S., Sridevi, V., Jayavelu, S., & Rajkumar, T. (2021). Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes. Gene, 790, 145697.

Liu, L., Zhang, X., Ding, H., Liu, X., Cao, D., Liu, Y., ... & Lu, J. (2021). Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS. Oncogene, 40(20), 3548-3563.

Klæstad, E., Opdahl, S., Engstrøm, M. J., Ytterhus, B., Wik, E., Bofin, A. M., & Valla, M. (2020). MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes. Breast cancer research and treatment, 180, 73-86.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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