Mouse Anti-MRPS25 (AA 1-173) Recombinant Antibody (CBFYM-0128) (CBMAB-M0148-FY)

Name: Mouse Anti-MRPS25 (AA 1-173) Recombinant Antibody (CBFYM-0128)
SKU: CBMAB-M0148-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0128

Application

WB, ELISA

Immunogen

Recombinant human MRPS25 (1-173aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-173

More Infomation

Target

Full Name

mitochondrial ribosomal protein S25

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

64432

UniProt ID

P82663

Alternative Names

Mitochondrial Ribosomal Protein S25; Mitochondrial Small Ribosomal Subunit Protein MS25; Mitochondrial 28S Ribosomal Protein S25; MRP-S25; RPMS25; S25mt; 28S Ribosomal Protein S25, Mitochondrial

Biological Process

Mitochondrial translation Source: ComplexPortal

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 50 (COXPD50):
An autosomal recessive, mitochondrial encephalomyopathy characterized by intrauterine growth retardation, poor overall growth, delayed psychomotor development, hypotonia, muscle weakness, progressive loss of ambulation, and mitochondrial oxidative phosphorylation deficiency in patient tissues. Brain imaging shows partial agenesis of the corpus callosum.

Bugiardini, E., Mitchell, A. L., Rosa, I. D., Horning-Do, H. T., Pitmann, A. M., Poole, O. V., ... & Spinazzola, A. (2019). MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy. Human Molecular Genetics, 28(16), 2711-2719.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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