Mouse Anti-MRPS7 (AA 38-242) Recombinant Antibody (CBFYM-2587) (CBMAB-M2775-FY)

Name: Mouse Anti-MRPS7 (AA 38-242) Recombinant Antibody (CBFYM-2587)
SKU: CBMAB-M2775-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2587

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 38-242

More Infomation

Target

Full Name

MITOCHONDRIAL RIBOSOMAL PROTEIN S7

Introduction

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.

Entrez Gene ID

51081

UniProt ID

Q9Y2R9

Alternative Names

Mitochondrial Ribosomal Protein S7; Mitochondrial Small Ribosomal Subunit Protein US7m; BMRP-27a; BMRP27a; MRP-S7; S7mt

Biological Process

Mitochondrial translation Source: UniProtKB
Ribosomal small subunit assembly Source: GO_Central
Translation Source: GO_Central

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 34 (COXPD34):
An autosomal recessive disorder caused by mitochondrial dysfunction and combined respiratory chain deficiencies of complexes I, III and IV. Clinical manifestations are variable and include congenital sensorineural deafness, lactic acidemia, and progressive hepatic and renal failure.

Kline, B. L., Jaillard, S., Bell, K. M., Bakhshalizadeh, S., Robevska, G., van den Bergen, J., ... & Tucker, E. J. (2022). Integral role of the mitochondrial ribosome in supporting ovarian function: MRPS7 variants in syndromic premature ovarian insufficiency. Genes, 13(11), 2113.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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