Mouse Anti-MS4A4A Recombinant Antibody (CBFYM-0212) (CBMAB-M0255-FY)

Name: Mouse Anti-MS4A4A Recombinant Antibody (CBFYM-0212)
SKU: CBMAB-M0255-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0212

Application

Immunogen

NS0 cells transfected with human MS4A4A

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MEMBRANE SPANNING 4-DOMAINS A4A

Introduction

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

51338

UniProt ID

Q96JQ5

Alternative Names

Membrane Spanning 4-Domains A4A; Membrane-Spanning 4-Domains, Subfamily A, Member 4; Four-Span Transmembrane Protein 1; CD20 Antigen-Like 1; 4SPAN1; CD20L1; MS4A4

Function

May be involved in signal transduction as a component of a multimeric receptor complex.

Cellular Location

Membrane

Topology

Cytoplasmic: 1-64
Helical: 65-85
Extracellular: 86-98
Helical: 99-119
Cytoplasmic: 120-137
Helical: 138-158
Extracellular: 159-179
Helical: 180-200
Cytoplasmic: 201-239

Li, Y., Shen, Z., Chai, Z., Zhan, Y., Zhang, Y., Liu, Z., ... & Deng, H. (2023). Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity. Gut, 72(12), 2307-2320.

You, S. F., Brase, L., Filipello, F., Iyer, A. K., Del-Aguila, J., He, J., ... & Dominantly Inherited Alzheimer Network. (2023). MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv.

Lightfoot, Y. L., Botte, A., Trinh, R. T. P., Ding, G. S., McReynolds, M., Allen, J. K., ... & Ray, W. J. (2023). Anti‐MS4A4A Antibody Modulates Myeloid Cell Biology and TREM2 Signaling. Alzheimer's & Dementia, 19, e072144.

Arthur, G. K., Ehrhardt-Humbert, L. C., Snider, D. B., Jania, C., Tilley, S. L., Metcalfe, D. D., & Cruse, G. (2020). The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells. Cellular signalling, 71, 109617.

Mattiola, I., Tomay, F., De Pizzol, M., Silva-Gomes, R., Savino, B., Gulic, T., ... & Locati, M. (2019). The interplay of the macrophage tetraspan MS4A4A with Dectin-1 and its role in NK cell-mediated resistance to metastasis. Nature immunology, 20(8), 1012.

Mattiola, I., Tomay, F., De Pizzol, M., Silva-Gomes, R., Savino, B., Gulic, T., ... & Locati, M. (2019). The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature immunology, 20(8), 1012-1022.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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