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Mouse Anti-MSH5 Recombinant Antibody (1C11) (CBMAB-A5607-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MSH5 (AAH02498, 736 a.a. ~ 835 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
mutS homolog 5 (E. coli)
Introduction
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing-over. This protein forms heterooligomers with another member of this family, mutS homolog 4. Alternative splicing results in four transcript variants encoding three different isoforms. [provided by RefSeq]
Entrez Gene ID
4439
UniProt ID
O43196
Alternative Names
DKFZp434C1615; G7; MGC2939; MutSH5; NG23
Function
Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).
Biological Process
Chiasma assembly Source: GO_Central
Mismatch repair Source: InterPro
Cellular Location
Nucleus
Involvement in disease
Premature ovarian failure 13 (POF13):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
More Infomation

Wyrwoll, M. J., Van Walree, E. S., Hamer, G., Rotte, N., Motazacker, M. M., Meijers-Heijboer, H., ... & Tüttelmann, F. (2022). Bi-allelic variants in DNA mismatch repair proteins MutS Homolog MSH4 and MSH5 cause infertility in both sexes. Human Reproduction, 37(1), 178-189.

Gong, C., Abbas, T., Muhammad, Z., Zhou, J., Khan, R., Ma, H., ... & Shi, B. (2022). A homozygous loss-of-function mutation in MSH5 abolishes MutSγ axial loading and causes meiotic arrest in NOA-affected individuals. International Journal of Molecular Sciences, 23(12), 6522.

Chen, M., Yao, C., Qin, Y., Cui, X., Li, P., Ji, Z., ... & Gao, F. (2022). Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing. Signal Transduction and Targeted Therapy, 7(1), 1.

Desjardins, S. D., Ogle, D. E., Ayoub, M. A., Heckmann, S., Henderson, I. R., Edwards, K. J., & Higgins, J. D. (2020). MutS homologue 4 and MutS homologue 5 maintain the obligate crossover in wheat despite stepwise gene loss following polyploidization. Plant Physiology, 183(4), 1545-1558.

AbdelGawwad, M. R., Marić, A., Al-Ghamdi, A. A., & Hatamleh, A. A. (2019). Interactome analysis and docking sites of MutS homologs reveal new physiological roles in Arabidopsis thaliana. Molecules, 24(13), 2493.

Milano, C. R., Holloway, J. K., Zhang, Y., Jin, B., Smith, C., Bergman, A., ... & Cohen, P. E. (2019). Mutation of the ATPase domain of MutS homolog-5 (MSH5) reveals a requirement for a functional MutSγ complex for all crossovers in mammalian meiosis. G3: Genes, Genomes, Genetics, 9(6), 1839-1850.

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For research use only. Not intended for any clinical use.

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