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Mouse Anti-MSL1 Recombinant Antibody (CBFYM-2642) (CBMAB-M2831-FY)

This product is mouse antibody that recognizes MSL1. The antibody CBFYM-2642 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MSL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2642
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MALE SPECIFIC LETHAL 1 HOMOLOG
Introduction
MSL1 is a Protein Coding gene. Among its related pathways are Chromatin organization.
Entrez Gene ID
339287
UniProt ID
Q68DK7
Alternative Names
Male Specific Lethal 1 Homolog; Male-Specific Lethal-1 Homolog 1; Male-Specific Lethal 1-Like 1; MSL1-Like 1; MSL-1; Male-Specific Lethal 1 Homolog (Drosophila); Male-Specific Lethal 1 Homolog; MSL1L1; HMSL1
Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571).

Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816).

This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816).

In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026).
Biological Process
Chromatin organization Source: UniProtKB-KW
Histone H4-K16 acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: Ensembl
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl
Cellular Location
Nucleus
nucleoplasm
Nucleus speckle
PTM
Sumoylated with SUMO1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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