Mouse Anti-MSL1 Recombinant Antibody (CBFYM-2642) (CBMAB-M2831-FY)

Name: Mouse Anti-MSL1 Recombinant Antibody (CBFYM-2642)
SKU: CBMAB-M2831-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2642

Application

WB, IP, IF, ELISA

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MALE SPECIFIC LETHAL 1 HOMOLOG

Introduction

MSL1 is a Protein Coding gene. Among its related pathways are Chromatin organization.

Entrez Gene ID

339287

UniProt ID

Q68DK7

Alternative Names

Male Specific Lethal 1 Homolog; Male-Specific Lethal-1 Homolog 1; Male-Specific Lethal 1-Like 1; MSL1-Like 1; MSL-1; Male-Specific Lethal 1 Homolog (Drosophila); Male-Specific Lethal 1 Homolog; MSL1L1; HMSL1

Function

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571).

Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816).

This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816).

In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026).

Biological Process

Chromatin organization Source: UniProtKB-KW
Histone H4-K16 acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: Ensembl
Regulation of dosage compensation by inactivation of X chromosome Source: Ensembl

Cellular Location

Nucleus
nucleoplasm
Nucleus speckle

PTM

Sumoylated with SUMO1.

He, Y., Wang, S., Liu, S., Qin, D., Liu, Z., Wang, L., ... & Zhang, L. (2023). MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation. Advanced Science, 2301094.

Krajewski, W. A., & Vassiliev, O. L. (2019). Analysis of histone ubiquitylation by MSL1/MSL2 proteins in vitro. Archives of biochemistry and biophysics, 666, 22-30.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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