Mouse Anti-MSRB2 Recombinant Antibody (2B7) (CBMAB-A5629-LY)

Name: Mouse Anti-MSRB2 Recombinant Antibody (2B7)
SKU: CBMAB-A5629-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2B7

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

MSRB2 (NP_036360, 102 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

methionine sulfoxide reductase B2

Entrez Gene ID

22921

UniProt ID

Q9Y3D2

Alternative Names

CBS-1; CBS1; CGI-131; MGC26104; MSRB; PILB

Function

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Biological Process

Actin filament polymerization Source: UniProtKB
Protein repair Source: HGNC-UCL
Response to oxidative stress Source: InterPro

Cellular Location

Mitochondrion

More Infomation

References

Wojciechowska, N., Bagniewska-Zadworna, A., Minicka, J., Michalak, K. M., & Kalemba, E. M. (2021). Localization and dynamics of the methionine sulfoxide reductases msrb1 and msrb2 in beech seeds. International Journal of Molecular Sciences, 22(1), 402.

Wojciechowska, N., Alipour, S., Stolarska, E., Bilska, K., Rey, P., & Kalemba, E. M. (2020). Peptide-bound methionine sulfoxide (MetO) levels and MsrB2 abundance are differentially regulated during the desiccation phase in contrasted Acer seeds. Antioxidants, 9(5), 391.

Bai, J., Wioland, H., Advedissian, T., Cuvelier, F., Romet-Lemonne, G., & Echard, A. (2020). Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy. Proceedings of the National Academy of Sciences, 117(8), 4169-4179.

Stolarska, E., Bilska, K., Wojciechowska, N., Bagniewska-Zadworna, A., Rey, P., & Kalemba, E. M. (2020). Integration of MsrB1 and MsrB2 in the redox network during the development of orthodox and recalcitrant Acer seeds. Antioxidants, 9(12), 1250.

Lee, S. H., Lee, S., Du, J., Jain, K., Ding, M., Kadado, A. J., ... & Hwa, J. (2019). Mitochondrial MsrB2 serves as a switch and transducer for mitophagy. EMBO molecular medicine, 11(8), e10409.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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